Multicenter Study

. 2020 Oct;277(10):2829-2838.

doi: 10.1007/s00405-020-06045-0. Epub 2020 May 25.

An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China

Shuifang Xiao¹, Jinrang Li², Hongliang Zheng³, Yan Yan⁴, Xiangping Li⁵, Lihong Zhang⁶, Quiping Lv⁷, Junbo Zhang⁸, Lin Zeng⁹, Xia Gao¹⁰, Xiong Chen^{11

12}, Hui Yang¹³, Chen Zhao¹⁴, Jian Zhang¹⁵, Honghua Lu¹⁶, Xianyang Luo¹⁷, Guangke Wang¹⁸, Hongliang Yi¹⁹, Jin Ye²⁰, Zhenqun Lin²¹, Linli Tian²², Jingjing Zhang²³, Ting Chen²⁴, Aimin Yu²⁵, Zhaohui Liu²⁶, Xiaoyong Ren²⁷, Xinming Yang²⁸, Siyi Zhang²⁹, Xiaobo Cui³⁰, Gelin Li³¹, Guanglun Wan³², Chang Lin³³, Hui Chen³⁴, Anchun Deng³⁵, Xiabing Tang³⁶, Qingfeng Zhang^{37

38}, Zhenfeng Tao³⁹, Li Shi⁴⁰, Jianyong Zhou⁴¹, Gang Qin⁴², Peiyun Zhuang⁴³, Hui Huangfu⁴⁴, Jianming Yang⁴⁵, Guojin Zhou⁴⁶, Huijun Li⁴⁷, Wei Wu⁴⁸, Julan Li⁴⁹, Shuhua Li⁵⁰, Guangming Lou⁵¹, Hongyan Fang⁵², Jiangang Ma⁵³, Chunguang Shan⁵³, Xuejun Zhou⁵⁴, Liang Tang⁵⁵, Fang Zhou⁵⁶, Yunping Fan⁵⁷, Yanping Zhang⁵⁸, Yujie Li⁵⁹, Meisheng Li⁶⁰, Chunqiang Dou⁶¹, Zhiling Chen⁶², Gang Lei⁶³, Jingbo Li⁶⁴, Zhiguang Gao⁶⁵, Yongwang Huang⁶⁶, Xinchun Ma⁶⁷, Zhijun Liu⁶⁸, Gengtian Liang⁶⁹, Jian He⁷⁰, Hua Zhao⁷¹, Bailong Song⁷², Meijun Chen⁷³, Xiangli Yang⁷⁴, Zuopeng Ma⁷⁵, Jinlong Ren⁷⁶

Affiliations

¹ Department of Otorhinolaryngology, Head and Neck Surgery, Peking University First Hospital, 8# Xishiku Street, Western District, Beijing, 100034, China. xiao_ent@163.com.
² Department of Otorhinolaryngology, Head and Neck Surgery, The Sixth Medical Center of Chinese PLA General Hospital, 6# Fucheng Road, Haidian District, Beijing, 100048, China. entljr@sina.com.
³ Department of Otorhinolaryngology, Head and Neck Surgery, Changhai Hospital, Second Military Medical University, 168# Changhai Street, Yangpu District, Shanghai, 200433, China. zheng_hl2004@163.com.
⁴ Department of Otorhinolaryngology, Head and Neck Surgery, Peking University Third Hospital, Beijing, China.
⁵ Department of Otorhinolaryngology, Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, Beijing, China.
⁷ Department of Otorhinolaryngology, Head and Neck Surgery, China-Japan Friendship Hospital, Beijing, China.
⁸ Department of Otorhinolaryngology, Head and Neck Surgery, Peking University First Hospital, 8# Xishiku Street, Western District, Beijing, 100034, China.
⁹ Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China.
¹⁰ Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
¹¹ Department of Otorhinolaryngology, Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
¹² Department of Otorhinolaryngology, Head and Neck Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
¹³ Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
¹⁴ Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
¹⁵ Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
¹⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Tianjin First Central Hospital, Tianjin, China.
¹⁷ Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
¹⁸ Department of Otorhinolaryngology Head and Neck Surgery, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
¹⁹ Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Sixth People's Hospital of Shanghai Jiaotong University, Shanghai, China.
²⁰ Department of Otorhinolaryngology, Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
²¹ Department of Otorhinolaryngology, Head and Neck Surgery, Hainan Provincial People's Hospital, Hiakou, Hainan, China.
²² Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
²³ Department of Otorhinolaryngology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
²⁴ Department of Otorhinolaryngology, Head and Neck Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, China.
²⁵ Department of Otorhinolaryngology, Head and Neck Surgery, Clinical Medical School, Yangzhou University, Yangzhou, Jiangsu, China.
²⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China.
²⁷ Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
²⁸ Department of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
²⁹ Department of Otorhinolaryngology Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China.
³⁰ Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
³¹ Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
³² Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui, China.
³³ Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
³⁴ Department of Otorhinolaryngology, Head and Neck Surgery, Chengdu First People's Hospital, Chengdu, Sichuan, China.
³⁵ Department of Otorhinolaryngology, Head and Neck Surgery, Xinqiao Hospital, Army Military Medical University, Chongqing, China.
³⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Wuxi People's Hospital, Wuxi, Jiangsu, China.
³⁷ Department of Otorhinolaryngology, Head and Neck Surgery, Dalian Central Hospital, Dalian, Liaoning, China.
³⁸ Department of Otorhinolaryngology, Head and Neck Surgery, Shenzhen University General Hospital, Shenzhen, Guangdong, China.
³⁹ Department of Otorhinolaryngology, Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang, Hebei, China.
⁴⁰ Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, China.
⁴¹ Department of Otorhinolaryngology Head and Neck Surgery, Jiangmen Central Hospital, Jiangmen, Guangdong, China.
⁴² Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
⁴³ Department of Voice, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.
⁴⁴ Department of Otorhinolaryngology, Head and Neck Surgery, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
⁴⁵ Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
⁴⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
⁴⁷ Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
⁴⁸ Department of Otorhinolaryngology, Head and Neck Surgery, PLA Strategic Support Force Characteristic Medical Center, Beijing, China.
⁴⁹ Department of Otorhinolaryngology Head and Neck Surgery, Sichuan Provincial Corps Hospital, Chinese People's Armed Police Force, Leshan, Sichuan, China.
⁵⁰ Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of Northern Theater Command, Shenyang, Liaoning, China.
⁵¹ Department of Otorhinolaryngology Head and Neck Surgery, The First Hospital of Longyan City, Longyan, Fujian, China.
⁵² Department of Otorhinolaryngology Head and Neck Surgery, Chongqing General Hospital, Chongqing, China.
⁵³ Department of Otorhinolaryngology, Head and Neck Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
⁵⁴ Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan, China.
⁵⁵ Department of Otorhinolaryngology, Head and Neck Surgery, The People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
⁵⁶ Department of Otorhinolaryngology Head and Neck Surgery, Changsha Central Hospital, Changsha, Hunan, China.
⁵⁷ Department of Otorhinolaryngology Head and Neck Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
⁵⁸ Department of Otorhinolaryngology Head and Neck Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
⁵⁹ Department of Otorhinolaryngology Head and Neck Surgery, Zhengzhou Central Hospital, Zhengzhou, Henan, China.
⁶⁰ Department of Otorhinolaryngology Head and Neck Surgery, The First People's Hospital of Shangqiu City, Shangqiu, Henan, China.
⁶¹ Department of Otorhinolaryngology, Head and Neck Surgery, Linfen People's Hospital, Linfen, Shanxi, China.
⁶² Department of Otorhinolaryngology, Head and Neck Surgery, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, China.
⁶³ Department of Otorhinolaryngology Head and Neck Surgery, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
⁶⁴ Department of Otorhinolaryngology Head and Neck Surgery, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, Henan, China.
⁶⁵ Department of Otorhinolaryngology Head and Neck Surgery, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China.
⁶⁶ Department of Otorhinolaryngology, Head and Neck Surgery, The Second Hospital of Tianjin Medical University, Tianjin, China.
⁶⁷ Department of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qinghai University, Xining, Qinghai, China.
⁶⁸ Department of Otorhinolaryngology, Head and Neck Surgery, Chizhou People's Hospital, Chizhou, Anhui, China.
⁶⁹ Department of Otorhinolaryngology, Head and Neck Surgery, Wuhan Third Hospital, Wuhan, Hubei, China.
⁷⁰ Department of Otorhinolaryngology, Head and Neck Surgery, Gansu Provincial Hospital, Lanzhou, Gansu, China.
⁷¹ Department of Otorhinolaryngology Head and Neck Surgery, Xinjiang Military Command General Hospital, Urumqi, Xinjiang, China.
⁷² Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Hospital of Chifeng College, Chifeng, Inner Mongolia, China.
⁷³ Department of Otorhinolaryngology Head and Neck Surgery, The People's Hospital of Dazu District, Chongqing, China.
⁷⁴ Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Union Medical Center, Tianjin, China.
⁷⁵ Department of Otorhinolaryngology Head and Neck Surgery, Qinghai Red Cross Hospital, Xining, Qinghai, China.
⁷⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Fenyang Hospital, Shanxi Province, Fenyang, Shanxi, China.

PMID: 32449029
DOI: 10.1007/s00405-020-06045-0

Multicenter Study

An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China

Shuifang Xiao et al. Eur Arch Otorhinolaryngol. 2020 Oct.

. 2020 Oct;277(10):2829-2838.

doi: 10.1007/s00405-020-06045-0. Epub 2020 May 25.

Authors

Affiliations

¹ Department of Otorhinolaryngology, Head and Neck Surgery, Peking University First Hospital, 8# Xishiku Street, Western District, Beijing, 100034, China. xiao_ent@163.com.
² Department of Otorhinolaryngology, Head and Neck Surgery, The Sixth Medical Center of Chinese PLA General Hospital, 6# Fucheng Road, Haidian District, Beijing, 100048, China. entljr@sina.com.
³ Department of Otorhinolaryngology, Head and Neck Surgery, Changhai Hospital, Second Military Medical University, 168# Changhai Street, Yangpu District, Shanghai, 200433, China. zheng_hl2004@163.com.
⁴ Department of Otorhinolaryngology, Head and Neck Surgery, Peking University Third Hospital, Beijing, China.
⁵ Department of Otorhinolaryngology, Head and Neck Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, Beijing, China.
⁷ Department of Otorhinolaryngology, Head and Neck Surgery, China-Japan Friendship Hospital, Beijing, China.
⁸ Department of Otorhinolaryngology, Head and Neck Surgery, Peking University First Hospital, 8# Xishiku Street, Western District, Beijing, 100034, China.
⁹ Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China.
¹⁰ Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
¹¹ Department of Otorhinolaryngology, Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
¹² Department of Otorhinolaryngology, Head and Neck Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
¹³ Department of Otorhinolaryngology, Head and Neck Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
¹⁴ Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
¹⁵ Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
¹⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Tianjin First Central Hospital, Tianjin, China.
¹⁷ Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.
¹⁸ Department of Otorhinolaryngology Head and Neck Surgery, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
¹⁹ Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Sixth People's Hospital of Shanghai Jiaotong University, Shanghai, China.
²⁰ Department of Otorhinolaryngology, Head and Neck Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
²¹ Department of Otorhinolaryngology, Head and Neck Surgery, Hainan Provincial People's Hospital, Hiakou, Hainan, China.
²² Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
²³ Department of Otorhinolaryngology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
²⁴ Department of Otorhinolaryngology, Head and Neck Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, China.
²⁵ Department of Otorhinolaryngology, Head and Neck Surgery, Clinical Medical School, Yangzhou University, Yangzhou, Jiangsu, China.
²⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China.
²⁷ Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
²⁸ Department of Otorhinolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
²⁹ Department of Otorhinolaryngology Head and Neck Surgery, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China.
³⁰ Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.
³¹ Department of Otorhinolaryngology, Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
³² Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Hospital, Hefei, Anhui, China.
³³ Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
³⁴ Department of Otorhinolaryngology, Head and Neck Surgery, Chengdu First People's Hospital, Chengdu, Sichuan, China.
³⁵ Department of Otorhinolaryngology, Head and Neck Surgery, Xinqiao Hospital, Army Military Medical University, Chongqing, China.
³⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Wuxi People's Hospital, Wuxi, Jiangsu, China.
³⁷ Department of Otorhinolaryngology, Head and Neck Surgery, Dalian Central Hospital, Dalian, Liaoning, China.
³⁸ Department of Otorhinolaryngology, Head and Neck Surgery, Shenzhen University General Hospital, Shenzhen, Guangdong, China.
³⁹ Department of Otorhinolaryngology, Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang, Hebei, China.
⁴⁰ Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, China.
⁴¹ Department of Otorhinolaryngology Head and Neck Surgery, Jiangmen Central Hospital, Jiangmen, Guangdong, China.
⁴² Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
⁴³ Department of Voice, Zhongshan Hospital, Xiamen University, Xiamen, Fujian, China.
⁴⁴ Department of Otorhinolaryngology, Head and Neck Surgery, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
⁴⁵ Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
⁴⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
⁴⁷ Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
⁴⁸ Department of Otorhinolaryngology, Head and Neck Surgery, PLA Strategic Support Force Characteristic Medical Center, Beijing, China.
⁴⁹ Department of Otorhinolaryngology Head and Neck Surgery, Sichuan Provincial Corps Hospital, Chinese People's Armed Police Force, Leshan, Sichuan, China.
⁵⁰ Department of Otorhinolaryngology Head and Neck Surgery, General Hospital of Northern Theater Command, Shenyang, Liaoning, China.
⁵¹ Department of Otorhinolaryngology Head and Neck Surgery, The First Hospital of Longyan City, Longyan, Fujian, China.
⁵² Department of Otorhinolaryngology Head and Neck Surgery, Chongqing General Hospital, Chongqing, China.
⁵³ Department of Otorhinolaryngology, Head and Neck Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
⁵⁴ Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan, China.
⁵⁵ Department of Otorhinolaryngology, Head and Neck Surgery, The People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China.
⁵⁶ Department of Otorhinolaryngology Head and Neck Surgery, Changsha Central Hospital, Changsha, Hunan, China.
⁵⁷ Department of Otorhinolaryngology Head and Neck Surgery, The Fifth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
⁵⁸ Department of Otorhinolaryngology Head and Neck Surgery, The 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
⁵⁹ Department of Otorhinolaryngology Head and Neck Surgery, Zhengzhou Central Hospital, Zhengzhou, Henan, China.
⁶⁰ Department of Otorhinolaryngology Head and Neck Surgery, The First People's Hospital of Shangqiu City, Shangqiu, Henan, China.
⁶¹ Department of Otorhinolaryngology, Head and Neck Surgery, Linfen People's Hospital, Linfen, Shanxi, China.
⁶² Department of Otorhinolaryngology, Head and Neck Surgery, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, China.
⁶³ Department of Otorhinolaryngology Head and Neck Surgery, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China.
⁶⁴ Department of Otorhinolaryngology Head and Neck Surgery, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou, Henan, China.
⁶⁵ Department of Otorhinolaryngology Head and Neck Surgery, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China.
⁶⁶ Department of Otorhinolaryngology, Head and Neck Surgery, The Second Hospital of Tianjin Medical University, Tianjin, China.
⁶⁷ Department of Otorhinolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qinghai University, Xining, Qinghai, China.
⁶⁸ Department of Otorhinolaryngology, Head and Neck Surgery, Chizhou People's Hospital, Chizhou, Anhui, China.
⁶⁹ Department of Otorhinolaryngology, Head and Neck Surgery, Wuhan Third Hospital, Wuhan, Hubei, China.
⁷⁰ Department of Otorhinolaryngology, Head and Neck Surgery, Gansu Provincial Hospital, Lanzhou, Gansu, China.
⁷¹ Department of Otorhinolaryngology Head and Neck Surgery, Xinjiang Military Command General Hospital, Urumqi, Xinjiang, China.
⁷² Department of Otorhinolaryngology, Head and Neck Surgery, Affiliated Hospital of Chifeng College, Chifeng, Inner Mongolia, China.
⁷³ Department of Otorhinolaryngology Head and Neck Surgery, The People's Hospital of Dazu District, Chongqing, China.
⁷⁴ Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Union Medical Center, Tianjin, China.
⁷⁵ Department of Otorhinolaryngology Head and Neck Surgery, Qinghai Red Cross Hospital, Xining, Qinghai, China.
⁷⁶ Department of Otorhinolaryngology, Head and Neck Surgery, Fenyang Hospital, Shanxi Province, Fenyang, Shanxi, China.

PMID: 32449029
DOI: 10.1007/s00405-020-06045-0

Abstract

Purpose: Using the Reflux Symptom Index (RSI), this nationwide study aimed to investigate the incidence, diagnostic status, risk factors, and common symptoms of adult laryngopharyngeal reflux disease (LPRD) at otorhinolaryngology-head and neck surgery (OHNS) clinics in China.

Methods: This multicenter cross-sectional survey began at the different institutions ranged from July to October 2017, and the duration was 12 months. A total of 90,440 eligible patients were finally enrolled from 72 medical institutions in China. All these patients completed the questionnaire based on RSI. In this study, LPRD was defined as RSI > 13.

Results: There were 9182 with LPRD among the 90,440 eligible participants (10.15%). However, only 1294 had a history of LPRD diagnosis among those with LPRD (14.09%). There were regional differences in the frequency of LPRD (P < 0.001). The proportions of patients with LPRD in males (vs. females), middle- and old-aged patients (vs. young), with current smoking history (vs. no smoking), and current drinking history (vs. no drinking) were significantly higher (all P < 0.001). Middle and old age, current smoking, and drinking history were independent predictors of LPRD (all P < 0.001, OR 1.240, 1.261, and 1.481, respectively). "Sensations of something stuck in throat or a lump in throat", "clearing throat", and "excess throat mucus or postnasal drip" were the most frequent clinical symptoms in patients with LPRD.

Conclusions: LPRD has a high incidence at the OHNS clinics in China. However, the diagnostic status of this disease is not optimistic. Older age, smoking, and drinking history were risk factors for LPRD.

Keywords: Cross-sectional survey; Laryngopharyngeal reflux; Multi-center; Otorhinolaryngology.

PubMed Disclaimer

Cited by

Practical multidisciplinary framework for the assessment and management of patients with unexplained chronic aerodigestive symptoms.
Quigley N, Mistry SG, Vasant DH, Vasani S. Quigley N, et al. BMJ Open Gastroenterol. 2023 Nov 23;10(1):e000883. doi: 10.1136/bmjgast-2022-000883. BMJ Open Gastroenterol. 2023. PMID: 37996120 Free PMC article. Review.
Awareness about laryngopharyngeal reflux disease among Chinese otolaryngologists: a nationwide survey.
Xiao S, Li J, Zheng H, Li X, Yang H, Zhang J, Peng X, Zhou S, Zhao C, Chen D, Xiao X, Shi L, Huangfu H, Tao Z, Chen X, Liu Y, Qu S, Wang G, Chen T, Cui X, Tian L, Zhou W, Fang H, Huang Y, Yu G, Lin Z, Tang L, He J, Ma R, Yu Z. Xiao S, et al. BMJ Open. 2022 Jun 22;12(6):e058852. doi: 10.1136/bmjopen-2021-058852. BMJ Open. 2022. PMID: 35732392 Free PMC article.
Pepsin concentration in oral lavage fluid of rabbit reflux model constructed by dilating the lower esophageal sphincter.
Sun Z, Wu W, Wang G, Li L, Wang L, Liu H. Sun Z, et al. Open Med (Wars). 2023 Sep 21;18(1):20230787. doi: 10.1515/med-2023-0787. eCollection 2023. Open Med (Wars). 2023. PMID: 37745979 Free PMC article.
[The application progress on diagnostic scales of laryngopharyngeal reflux disease].
Han Y, Zhang S, Huangfu H, Liu C, Yan C. Han Y, et al. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2023 Apr;37(4):313-317. doi: 10.13201/j.issn.2096-7993.2023.04.016. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2023. PMID: 36987966 Free PMC article. Review. Chinese.
Weak acid and pepsin reflux induce laryngopharyngeal mucosal barrier injury: A rabbit-model-based study.
Hou C, Zhou L, Zheng Y, Chen T, Hu R, Zheng J, Liu C, Liu Y. Hou C, et al. PLoS One. 2025 Jan 24;20(1):e0315083. doi: 10.1371/journal.pone.0315083. eCollection 2025. PLoS One. 2025. PMID: 39854415 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Springer

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China

Affiliations

An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Related information

LinkOut - more resources

Full Text Sources