Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jul;140(1):85-87.
doi: 10.1007/s00401-020-02165-3. Epub 2020 May 24.

Spatial enrichment of cellular states in glioblastoma

Charles G Eberhart  1 , Eli E Bar  2   3
Affiliations

Spatial enrichment of cellular states in glioblastoma

Charles G Eberhart et al. Acta Neuropathol. 2020 Jul.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Cellular States are Enriched in Specific Anatomical Features of Glioblastoma. (a) Summary of the enriched cellular states in the five anatomical regions analyzed within GBM by the IvyGAP project. Averaged, log2-transformed, expression of cellular state signature genes in (b) - Microvascular proliferation (MVP). (c) Infiltrating Tumor (IT); (d) - Leading Edge (LE); (e) - Pseudopallisading cells around necrosis (PAN); and (F) - Cellular Tumor (CT). Abbreviations: NPC - Neural Precursor-Like, OPC - Oligodendrocyte Precursor-Like, AC - Astrocyte-Like, MES - Mesenchymal-Like. Statistics: One-way ANOVA with Tukey’s multiple comparisons test. * p<0.05, ** p<0.01, & p<0.001, # p<0.0001.
See this image and copyright information in PMC

References

    1. Bar EE (2011) Glioblastoma, cancer stem cells and hypoxia. Brain Pathol 21: 119–129 Doi 10.1111/j.1750-3639.2010.00460.x - DOI - PMC - PubMed
    1. Bar EE, Lin A, Mahairaki V, Matsui W, Eberhart CG (2010) Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres. Am J Pathol 177: 1491–1502 Doi S0002-9440(10)60201-510.2353/ajpath.2010.091021 - PMC - PubMed
    1. Calabrese C, Poppleton H, Kocak M, Hogg TL, Fuller C, Hamner B, Oh EY, Gaber MW, Finklestein D, Allen M et al (2007) A perivascular niche for brain tumor stem cells. Cancer Cell 11: 69–82 Doi S1535-6108(06)00369-210.1016/j.ccr.2006.11.020 - PubMed
    1. Dirks PB (2010) Brain tumor stem cells: the cancer stem cell hypothesis writ large. Mol Oncol 4: 420–430 Doi 10.1016/j.molonc.2010.08.001S1574-7891(10)00082-7 - DOI - PMC - PubMed
    1. Li Z, Bao S, Wu Q, Wang H, Eyler C, Sathornsumetee S, Shi Q, Cao Y, Lathia J, McLendon RE et al (2009) Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15: 501–513 Doi S1535-6108(09)00087-710.1016/j.ccr.2009.03.018 - PMC - PubMed

Publication types