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Review
. 2020 Jun;47(6):4691-4698.
doi: 10.1007/s11033-020-05518-z. Epub 2020 May 25.

Dependence between estrogen sulfotransferase (SULT1E1) and nuclear transcription factor Nrf-2 regulations via oxidative stress in breast cancer

Aarifa Nazmeen  1 , Guangping Chen  2 , Smarajit Maiti  3
Affiliations
Review

Dependence between estrogen sulfotransferase (SULT1E1) and nuclear transcription factor Nrf-2 regulations via oxidative stress in breast cancer

Aarifa Nazmeen et al. Mol Biol Rep. 2020 Jun.

Abstract

Human estrogen sulfotransferase (SULT1E1) and nuclear factor erythroid 2-related factor 2 (Nrf-2) expression influences each other in advanced human breast carcinogenesis. The difference in the metabolism of estradiol (E2) in pre- and post-menopausal women remains to be connected with post-menopausal breast cancer. A synergism between ROS production and E2 generation has been demonstrated. No definite mechanism for simultaneous functions of Nrf2, oxidative stress E2 regulating enzymes (SULT1E1) has been yet clarified. Our present review demonstrates that ROS dependent regulation of Nrf-2 is one of the most important determinants of E2 regulation by altering SULT1E1 expression. This study also focuses the idea that estrogen receptor cased subtypes of cancer may have different molecular environments which has an impact on the therapeutic efficacy.

Keywords: Breast cancer; Estrogen regulations; Nrf-2 and SULT1E1 expressions; Oxidative stress.

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Conflict of interest statement

Conflict of interest None.

Figures

Fig. 1
Fig. 1
Expression of Nrf2 and SULT1E1 protein in tumor tissue and adjacent surrounding breast tissue in breast cancer patients. Demarcated arrows are (1) Adipose tissue, (2) Low Nrf2 expression in stromal and cellular regions, (3) Highly expressed Nrf2, (4) Stromal region, (5) Adipose tissue, (6) Stromal region with low expression of SULT1E1, (7) Adipose tissue, (8) Increased expression of SULT1E1 in the stromal region
Fig. 2
Fig. 2
Immunohistochemistry of rat liver tissues. Tumor shows an increased expression of Nrf-2 as compared to their corresponding surrounding tissue. The red arrows are pointing the central vein
Fig. 3
Fig. 3
Stress activation of Nrf2 and HNF α mediated induction of SULT1E1 and its role in Estradiol regulation via P13K pathway
See this image and copyright information in PMC

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