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Editorial
. 2021 Jan 1;117(1):15-17.
doi: 10.1093/cvr/cvaa149.

Cyclophilin D palmitoylation and permeability transition: a new twist in the tale of myocardial ischaemia-reperfusion injury

Alice Main  1 , Olivia Robertson-Gray  1 , William Fuller  1
Affiliations
Editorial

Cyclophilin D palmitoylation and permeability transition: a new twist in the tale of myocardial ischaemia-reperfusion injury

Alice Main et al. Cardiovasc Res. .
No abstract available

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Figures

Figure 1
Figure 1
CypD C202 Modification in Cardiac Mitochondria. Amanakis et al. demonstrate that under basal conditions, the mitochondrial permeability transition pore (PTP) regulator cyclophillin-D (CypD) is reported to be both S-nitrosylated and S-palmitoylated at position cysteine 202 (C202). Under conditions of ischaemia, CypD S-palmitoylation and S-nitrosylation are reduced as C202 undergoes oxidation. This leads to greater association of CypD with the F1-ATPase subunit of the PTP and enhances pore opening and calcium efflux at reperfusion, thus leading to greater myocardial damage and increased infarct size. Mutation of C202 to a serine (S) results in no possible modification by S-nitrosylation, S-palmitoylation but also S-oxidation and transgenic mice have significantly reduced infarct size and enhanced functional recovery as a result.
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Comment on

References

    1. Hausenloy DJ, Yellon DM.. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J Clin Invest 2013;123:92–100. - PMC - PubMed
    1. Baines CP, Kaiser RA, Purcell NH, Blair NS, Osinska H, Hambleton MA, Brunskill EW, Sayen MR, Gottlieb RA, Dorn GW, Robbins J, Molkentin JD.. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature 2005;434:658–662. - PubMed
    1. Piot C, Croisille P, Staat P, Thibault H, Rioufol G, Mewton N, Elbelghiti R, Cung TT, Bonnefoy E, Angoulvant D, Macia C, Raczka F, Sportouch C, Gahide G, Finet G, André-Fouët X, Revel D, Kirkorian G, Monassier J-P, Derumeaux G, Ovize M.. Effect of cyclosporine on reperfusion injury in acute myocardial infarction. N Engl J Med 2008;359:473–481. - PubMed
    1. Zografos TA, Katritsis DG.. Cyclosporine before PCI in acute myocardial infarction. N Engl J Med 2016;374:88–90. - PubMed
    1. Amanakis G, Sun J, Fergusson MM, Mcginty S, Liu C, Molkentin JD, Murphy E. Cysteine 202 of cyclophilin D is a site of multiple post-translational modifications and plays a role in cardioprotection. Cardiovasc Res 2021;117:212–223. - PMC - PubMed