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Case Reports
. 2020 Sep;67(9):e28330.
doi: 10.1002/pbc.28330. Epub 2020 May 26.

A newborn with a large NTRK fusion positive infantile fibrosarcoma successfully treated with larotrectinib

Kenneth J Caldwell  1 , Esther De La Cuesta  2 , Cara Morin  3 , Alberto Pappo  1 , Sara Helmig  1
Affiliations
Case Reports

A newborn with a large NTRK fusion positive infantile fibrosarcoma successfully treated with larotrectinib

Kenneth J Caldwell et al. Pediatr Blood Cancer. 2020 Sep.

Abstract

Infantile fibrosarcoma (IFS) is a rare pediatric cancer that typically presents early in life. Surgical resection is commonly curative; however, resection is sometimes not possible requiring additional multimodal treatment. IFS commonly harbors a fusion in one of the neurotrophic receptor tyrosine kinase (NTRK) genes. Larotrectinib, a highly selective inhibitor of tropomyosin receptor kinase (TRK), has been shown to be well tolerated and effective in children as young as 1-month old. We report a case of IFS in a newborn treated with larotrectinib. The patient experienced a rapid clinical and radiographic response demonstrating the potential to treat newborns with larotrectinib.

Keywords: NTRK; infantile fibrosarcoma; larotrectinib; pediatric.

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References

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