Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Practice Guideline
. 2020 May;18(3):163-166.
doi: 10.2450/2020.0124-20.

Position paper on the preparation of immune plasma to be used in the treatment of patients with COVID-19

Patrizia Accorsi  1 , Pierluigi Berti  2 , Vincenzo de Angelis  3 , Giustina De Silvestro  4 , Luca Mascaretti  5 , Angelo Ostuni  6 ; Italian Society for Transfusion Medicine and Immunohaematology (SIMTI) and the Italian Society for Haemapheresis and Cell Manipulation (SIdEM)
Affiliations
Practice Guideline

Position paper on the preparation of immune plasma to be used in the treatment of patients with COVID-19

Patrizia Accorsi et al. Blood Transfus. 2020 May.

Abstract

Passive immunotherapy with plasma derived from convalescent patients recovering from SARS-CoV-2 infection can be a promising approach in the treatment of COVID-19 patients. It is important that blood establishments are ready to satisfy requests for immune plasma by defining the requirements applicable to plasma donors and the standards for preparation, qualification, storage, distribution, and control of product use. This Position paper aims to give recommendations on the biological characteristics of a plasma preparation from convalescent donors and to support the evaluation of this therapeutic approach in more rigorous investigations.

PubMed Disclaimer

Conflict of interest statement

The Authors declare no conflicts of interest.

References

    1. Chen L, Xiong J, Bao L, Shi Y. Convalescent plasma as a potential therapy for COVID-19. Lancet Infect Dis. 2020;20:398–400. - PMC - PubMed
    1. Shen C, Wang Z, Zhao F, et al. Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma. JAMA. 2020;323:1582–9. - PMC - PubMed
    1. Huaxia c[internet] China puts 245 COVID-19 patients on convalescent plasma therapy. [Accessed on: 30/03/2020]. Available at: http://www.xinhuanet.com/english/2020-02/28/c_138828177.htm.
    1. Casadevall A, Pirofski LA. The convalescent sera option for containing COVID-19. J Clin Invest. 2020 doi: 10.1172/JCI138003. [Online ahead of print.] - DOI - PMC - PubMed
    1. Roback JD, Guarner J. Convalescent Plasma to Treat COVID-19: possibilities and challenges. JAMA. 2020 doi: 10.1001/jama.2020.4940. [Online ahead of print.] - DOI - PubMed

Publication types

MeSH terms

Substances