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. 2020 Aug;190(3):e126-e127.
doi: 10.1111/bjh.16888. Epub 2020 Jun 28.

Haemoglobin oxygen affinity in patients with severe COVID-19 infection

Affiliations

Haemoglobin oxygen affinity in patients with severe COVID-19 infection

Yvonne Daniel et al. Br J Haematol. 2020 Aug.
No abstract available

Keywords: COVID-19; haemoglobin; hypoxaemia; oxygen affinity; oxygen association; oxygen dissociation.

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Figures

Fig 1
Fig 1
Haemoglobin O2 affinity curves from patients testing positive for COVID‐19 and age‐ and sex‐matched controls. Measurements were made using a Hemox Analyzer (TCS Scientific, New Hope, PA, USA) at pH 7·4 and 37°C. Each dataset from each sample was fitted using a sigmoidal function with variable Hill Slope according to the equation O2 Sat (%) = Bottom + [(Top − Bottom)/1 + 10^(LogEC50 − PO2) * HillSlope] where the 'Top' was constrained to 100%. The data points shown, and the P50 and Hill Slope values in Table I, were derived from each sample, and each fitted curve, and averaged to give a mean ± SD [n = 14 (COVID‐19 positive), n = 11 (Control)]. The curves shown are fitted to the average data points using the same equation. Confidence intervals are small and overlapping (not shown).

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