Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Oct-Dec;25(4):283-8.
doi: 10.1007/BF02581126.

The influence of increasing glucose concentrations on selected functions of polymorphonuclear neutrophils

B Wierusz-Wysocka  1 , H Wysocki, A Wykretowicz, R Klimas
Affiliations

The influence of increasing glucose concentrations on selected functions of polymorphonuclear neutrophils

B Wierusz-Wysocka et al. Acta Diabetol Lat. 1988 Oct-Dec.

Abstract

The influence of increasing glucose concentrations on some essential functions in polymorphonuclear neutrophils (PMN) was evaluated in vitro in 20 healthy persons. PMN chemotaxis, adherence, phagocytosis and bactericidal capacity were estimated. Higher than physiologic glucose concentrations were found to diminish chemotaxis, phagocytosis and bactericidal capacity. The results obtained may indicate another possible mechanism that accounts for the increased susceptibility to infection observed in diabetic patients. However, PMN adherence rose parallel with increasing glucose concentrations reaching maximum values at 300 mg/dl (16.6 mmol/l). The changes of PMN adherence may suggest the participation of these cells in the development of microangiopathic injuries.

PubMed Disclaimer

References

    1. J Exp Med. 1977 Sep 1;146(3):641-52 - PubMed
    1. J Reticuloendothel Soc. 1979 Aug;26(2):155-70 - PubMed
    1. Diabetes. 1978 Jun;27(6):677-81 - PubMed
    1. J Clin Invest. 1985 Aug;76(2):535-42 - PubMed
    1. Diabetes. 1982 Dec;31(12):1041-3 - PubMed