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Review
. 2021 Feb;53(1):e13645.
doi: 10.1111/and.13645. Epub 2020 May 26.

Protein profiling in unlocking the basis of varicocele-associated infertility

Manesh Kumar Panner Selvam  1 , Saradha Baskaran  1 , Ashok Agarwal  1 , Ralf Henkel  1   2
Affiliations
Review

Protein profiling in unlocking the basis of varicocele-associated infertility

Manesh Kumar Panner Selvam et al. Andrologia. 2021 Feb.

Abstract

Varicocele is one of the major causes of male infertility and has a negative impact on spermatogenesis. The conventional semen analysis does not reveal the underlying subcellular mechanisms associated with defects in spermatozoa. Proteomics and bioinformatics analysis can be used to identify the molecular aetiologies associated with poor semen quality in varicocele patients. Mitochondrial dysfunction has been identified as the main factor affecting normal physiological functions of spermatozoa. This article discusses the proteomic studies of spermatozoa and seminal plasma in varicocele patients. Proteomics can identify potential spermatozoa and seminal plasma biomarkers in varicocele-mediated male infertility. In future, these protein biomarkers can be useful in the development of noninvasive diagnostic and therapeutic strategies for varicocele patients.

Keywords: bioinformatics; proteomics; seminal plasma; spermatozoa; varicocele.

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References

REFERENCES

    1. Abdallah, C., Dumas-Gaudot, E., Renaut, J., & Sergeant, K. (2012). Gel-based and gel-free quantitative proteomics approaches at a glance. International Journal of Plant Genomics, 2012, 1-17. https://doi.org/10.1155/2012/494572
    1. Agarwal, A., Durairajanayagam, D., Halabi, J., Peng, J., & Vazquez-Levin, M. (2014). Proteomics, oxidative stress and male infertility. Reproductive BioMedicine Online, 29(1), 32-58.
    1. Agarwal, A., Gupta, S., & Sharma, R. (2016). Oxidation-reduction potential measurement in ejaculated semen samples. In Andrological evaluation of male infertility (pp. 165-170). Berlin: Springer.
    1. Agarwal, A., Panner Selvam, M. K., Baskaran, S., & Cho, C. L. (2019). Sperm DNA damage and its impact on male reproductive health: A critical review for clinicians, reproductive professionals and researchers. Expert Review of Molecular Diagnostics, 19(6), 443-457.
    1. Agarwal, A., Sharma, R., Durairajanayagam, D., Ayaz, A., Cui, Z., Willard, B., … Sabanegh, E. (2015). Major protein alterations in spermatozoa from infertile men with unilateral varicocele. Reproductive Biology and Endocrinology, 13(1), 8. https://doi.org/10.1186/s12958-015-0007-2

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