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. 2020 Jun 8;37(6):738-741.
doi: 10.1016/j.ccell.2020.04.018. Epub 2020 Apr 29.

The COVID-19 and Cancer Consortium: A Collaborative Effort to Understand the Effects of COVID-19 on Patients with Cancer

Affiliations

The COVID-19 and Cancer Consortium: A Collaborative Effort to Understand the Effects of COVID-19 on Patients with Cancer

Samuel M Rubinstein et al. Cancer Cell. .

Abstract

National and international consortia will play a key role in understanding the effects of the coronavirus disease 2019 (COVID-19) pandemic on cancer patients. The COVID-19 and Cancer Consortium (CCC19) aims to collect and analyze observational data at scale to inform clinical practice in real-time.

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Conflict of interest statement

J.W. reports consulting for Westat, is a member of the IBM Health Watson Oncology and Genomics advisory council, and is cofounder of HemOnc.org LLC (no monetary value). B.I.R. reports consulting for Merck and research funding to institution for Merck, BMS, Pfizer, Aveo, Astra-Zeneca, and Genentech and holds stock in PTC therapeutics. S.P. has received education grants, provided consultation, attended advisory boards, and/or provided lectures for Abbvie, Amgen, AstraZeneca, Bayer, Biocartis, Bioinvent, Blueprint Medicines, Boehringer-Ingelheim, Bristol-Myers Squibb, Clovis, Daiichi Sankyo, Debiopharm, Eli Lilly, F. Hoffmann-La Roche, Foundation Medicine, Illumina, Janssen, Merck Sharp and Dohme, Merck Serono, Merrimack, Novartis, Pharma Mar, Pfizer, Regeneron, Sanofi, Seattle Genetics, Takeda, and Vaccibody, from whom she has received honoraria (all fees to institution). T.K.C. reports research (institutional and personal) for AstraZeneca, Alexion, Bayer, Bristol Myers-Squibb/ER Squibb and Sons LLC, Cerulean, Eisai, Foundation Medicine Inc., Exelixis, Ipsen, Tracon, Genentech, Roche, Roche Products Limited, F. Hoffmann-La Roche, GlaxoSmithKline, Lilly, Merck, Novartis, Peloton, Pfizer, Prometheus Labs, Corvus, Calithera, Analysis Group, Sanofi/Aventis, and Takeda; honoraria from AstraZeneca, Alexion, Sanofi/Aventis, Bayer, Bristol Myers-Squibb/ER Squibb and Sons LLC, Cerulean, Eisai, Foundation Medicine Inc., Exelixis, Genentech, Roche, Roche Products Limited, F. Hoffmann-La Roche, GlaxoSmithKline, Merck, Novartis, Peloton, Pfizer, EMD Serono, Prometheus Labs, Corvus, Ipsen, Up-to-Date, NCCN, Analysis Group, NCCN, and Michael J. Hennessy (MJH) Associates, Inc. (Healthcare Communications Company with several brands such as OnClive, PeerView and PER); research to practice for L-path, Kidney Cancer Journal, Clinical Care Options, Platform Q, Navinata Healthcare, Harborside Press, American Society of Medical Oncology, NEJM, Lancet Oncology, Heron Therapeutics, and Lilly; consulting or advisory role for AstraZeneca, Alexion, Sanofi/Aventis, Bayer, Bristol Myers-Squibb/ER Squibb and Sons LLC, Cerulean, Eisai, Foundation Medicine Inc., Exelixis, Genentech, Heron Therapeutics, Lilly, Roche, GlaxoSmithKline, Merck, Novartis, Peloton, Pfizer, EMD Serono, Prometheus Labs, Corvus, Ipsen, Up-to-Date, NCCN, Analysis Group, Pionyr, Tempest; stock ownership in Pionyr and Tempest; and other present or past leadership roles: Director of GU Oncology Division at Dana-Farber and past President of medical Staff at Dana-Farber), member of NCCN Kidney panel and the GU Steering Committee, past chairman of the Kidney Cancer Association Medical and Scientific Steering Committee); patents, royalties, or other intellectual properties: International Patent Application No. PCT/US2018/12209, entitled “PBRM1 Biomarkers Predictive of Anti-Immune Checkpoint Response,” filed January 3, 2018, claiming priority to U.S. Provisional Patent Application No. 62/445,094, filed January 11, 2017; international patent application No. PCT/US2018/058430, titled “Biomarkers of Clinical Response and Benefit to Immune Checkpoint Inhibitor Therapy,” filed October 31, 2018, claiming priority to U.S. Provisional Patent Application No. 62/581,175, filed November 3, 2017; medical writing and editorial assistance support may have been funded by Communications companies funded by pharmaceutical companies (ClinicalThinking, Envision Pharma Group, Fishawack Group of Companies, Health Interactions, Parexel, Oxford PharmaGenesis, and others); the institution (Dana-Farber Cancer Institute) may have received additional independent funding of drug companies or/and royalties potentially involved in research around the subject matter. Mentored several non-US citizens on research projects with potential funding (in part) from non-U.S. sources/Foreign Components. CV provided upon request for scope of clinical practice and research.

Figures

Figure 1
Figure 1
Geographic Participation and Patient Accrual in the CCC19 (A) Schematic indicating institutions that are participating in the CCC19 as of April 16, 2020. The sites are a combination of National Cancer Institute-designated comprehensive cancer centers, academic institutions, and community-based institutions. (B) Chart demonstrating exponential growth in reported cases over time (n = 1,040 as of a data lock on April 16, 2020) for analysis in the first CCC19 publication.

References

    1. Bersanelli M. Controversies about COVID-19 and anticancer treatment with immune checkpoint inhibitors. Immotherapy. 2020;12 doi: 10.2217/imt-2020-0067. Published online March 26, 2020. - DOI - PMC - PubMed
    1. Biagi J.J., Raphael M.J., Mackillop W.J., Kong W., King W.D., Booth C.M. Association between time to initiation of adjuvant chemotherapy and survival in colorectal cancer: a systematic review and meta-analysis. JAMA. 2011;305:2335–2342. - PubMed
    1. Bleicher R.J., Ruth K., Sigurdson E.R., Beck J.R., Ross E., Wong Y.-N., Patel S.A., Boraas M., Chang E.I., Topham N.S., Egleston B.L. Time to surgery and breast cancer survival in the United States. JAMA Oncol. 2016;2:330–339. - PMC - PubMed
    1. Dai M., Liu D., Liu M., Zhou F., Li G., Chen Z., Zhang Z., You H., Wu M., Zheng Q. Patients with cancer appear more vulnerable to SARS-CoV-2: a multicenter study during the COVID-19 outbreak. Cancer Discov. 2020 doi: 10.1158/2159-8290.CD-20-0422. Published online April 28, 2020. - DOI - PMC - PubMed
    1. Desai A., Warner J., Kuderer N., Thompson M., Painter C., Lyman G., Lopes G. Crowdsourcing a crisis response for COVID-19 in oncology. Nat. Cancer. 2020 doi: 10.1038/s43018-020-0065-z. Published online April 21, 2020. - DOI - PubMed

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