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. 2021 Jan;141(1):206-209.e1.
doi: 10.1016/j.jid.2020.05.087. Epub 2020 May 23.

High Expression of ACE2 on Keratinocytes Reveals Skin as a Potential Target for SARS-CoV-2

Xiaotong Xue  1 , Zihao Mi  1 , Zhenzhen Wang  1 , Zheng Pang  1 , Hong Liu  2 , Furen Zhang  1
Affiliations

High Expression of ACE2 on Keratinocytes Reveals Skin as a Potential Target for SARS-CoV-2

Xiaotong Xue et al. J Invest Dermatol. 2021 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Expression of ACE2 in skin tissues in public database. (a) Bar plot of ACE2 expression in human normal tissues from GEPIA2 database. Expression level was indicated by log2(mean of TPM + 1). (b) Boxplot of ACE2 in different tissue types from ARCHS4 database. TPM, transcript per million.
Figure 2
Figure 2
ACE2 RNA and protein expression in skin tissues. (a) Violin plot of ACE2 expression in bulk RNA sequencing of skin tissues. Expression level was indicated by log2(FPKM). (b) Amplification curve of skin samples and negative control from qRT-PCR. (c) Eight primary cell types in skin tissues were identified by cell markers, and cells were clustered by the UMAP method. (d) Cells with positive (red plots) ACE2 expression. (e) Violin plot of ACE2 expression in different cell types. Expression level was indicated by log2(UMI counts). (f) Violin plot of ACE2 expression in different cell subtypes of skin keratinocytes. Expression level was indicated by log2(UMI counts). (g) ACE2 protein expression in human skin tissues (original magnification, ×200). FPKM, fragments per kilobase million; qRT-PCR, quantitative real-time RT-PCR; UMAP, uniform manifold approximation and projection; UMI, unique molecular identifier.
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