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. 2020 Jul:87:182-183.
doi: 10.1016/j.bbi.2020.05.057. Epub 2020 May 23.

The role of IgA in COVID-19

Yin Xia Chao  1 , Olaf Rötzschke  2 , Eng-King Tan  3
Affiliations

The role of IgA in COVID-19

Yin Xia Chao et al. Brain Behav Immun. 2020 Jul.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Mucosal Immunity in the nostril upon SARS-CoV-2 infection. Upon SARSE-CoV-2 infection in the nostril, both innate and adaptive immunity at the epithelium will be activated. Plasma cells, which can be the target of mucosal vaccine, produce IgA and secreted into the mucus where they meet and neutralize the invaded virus through binding to the Spike protein on the surface of SARS-Cov-2. Upon large dose of virus infection or a decreased secretory IgA response, virus will break through the barrier and infect the epithelia cells and other cells such as macrophages in the tissue through the interaction of RBD on Spike protein and ACE-2. Other neutralization antibodies can also bind to SARS-Cov-2 to prevent it from infecting other cells. However, the binding of non-neutralization antibodies may help SARS-Cov-2 entering the cells through Fc-Fc receptor interaction and cause antibody dependent enhancement (ADE).
See this image and copyright information in PMC

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