Subclinical Acute Kidney Injury in COVID-19 Patients: A Retrospective Cohort Study

Dan-Qin Sun¹, Ting-Yao Wang², Kenneth I Zheng³, Giovanni Targher⁴, Christopher D Byrne⁵, Yong-Ping Chen^{3

6

7}, Ming-Hua Zheng^{8

9

10}

Affiliations

¹ Department of Nephrology, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, China.
² Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
³ NAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
⁴ Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
⁵ Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton General Hospital, Southampton, United Kingdom.
⁶ Institute of Hepatology, Wenzhou Medical University, Wenzhou, China.
⁷ Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China.
⁸ NAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China, zhengmh@wmu.edu.cn.
⁹ Institute of Hepatology, Wenzhou Medical University, Wenzhou, China, zhengmh@wmu.edu.cn.
¹⁰ Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China, zhengmh@wmu.edu.cn.

PMID: 32454505
PMCID: PMC7270065
DOI: 10.1159/000508502

Comment

Subclinical Acute Kidney Injury in COVID-19 Patients: A Retrospective Cohort Study

Dan-Qin Sun et al. Nephron. 2020.

. 2020;144(7):347-350.

doi: 10.1159/000508502. Epub 2020 May 26.

Authors

Dan-Qin Sun¹, Ting-Yao Wang², Kenneth I Zheng³, Giovanni Targher⁴, Christopher D Byrne⁵, Yong-Ping Chen^{3

6

7}, Ming-Hua Zheng^{8

9

10}

Affiliations

¹ Department of Nephrology, The Affiliated Wuxi No. 2 People's Hospital of Nanjing Medical University, Wuxi, China.
² Department of Nephrology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
³ NAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
⁴ Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
⁵ Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton General Hospital, Southampton, United Kingdom.
⁶ Institute of Hepatology, Wenzhou Medical University, Wenzhou, China.
⁷ Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China.
⁸ NAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China, zhengmh@wmu.edu.cn.
⁹ Institute of Hepatology, Wenzhou Medical University, Wenzhou, China, zhengmh@wmu.edu.cn.
¹⁰ Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China, zhengmh@wmu.edu.cn.

PMID: 32454505
PMCID: PMC7270065
DOI: 10.1159/000508502

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

**Fig. 1**
The proportion of proteinuria (a) and the mean levels of eGFR (b) across different disease subtypes of COVID-19 patients during the hospital stay; Kaplan-Meier curves for cumulative hospital discharge rates of COVID-19 patients stratified by urinary levels of kidney injury biomarkers (urinary α1MG (c); urinary β2MG (d)). eGFR, estimated glomerular filtration rate; α1MG, α1-microglobulin; β2MG, β2-microglobulin.

See this image and copyright information in PMC

Comment on

COVID-19 Infection in a Patient with End-Stage Kidney Disease.
Fu D, Yang B, Xu J, Mao Z, Zhou C, Xue C. Fu D, et al. Nephron. 2020;144(5):245-247. doi: 10.1159/000507261. Epub 2020 Mar 27. Nephron. 2020. PMID: 32222703 Free PMC article.

References

1. Fu D, Yang B, Xu J, Mao Z, Zhou C, Xue C. COVID-19 infection in a patient with end-stage kidney disease. Nephron. 2020 doi: 10.1159/000507261. - DOI - PMC - PubMed
1. Zhang F, Liang Y. Potential risk of the kidney vulnerable to novel coronavirus 2019 infection. Am J Physiol Ren Physiol. 2020;318((5)):F1136–F7. - PMC - PubMed
1. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395((10223)):507–13. - PMC - PubMed
1. Naicker S, Yang CW, Hwang SJ, Liu BC, Chen JH, Jha V. The Novel Coronavirus 2019 epidemic and kidneys. Kidney Int. 2020;97((5)):824–8. - PMC - PubMed
1. Desanti De Oliveira B, Xu K, Shen TH, Callahan M, Kiryluk K, D'Agati VD, et al. Molecular nephrology: types of acute tubular injury. Nat Rev Nephrol. 2019;15((10)):599–612. - PMC - PubMed

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Subclinical Acute Kidney Injury in COVID-19 Patients: A Retrospective Cohort Study

Affiliations

Subclinical Acute Kidney Injury in COVID-19 Patients: A Retrospective Cohort Study

Authors

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Conflict of interest statement

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