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Review
. 2017 Apr;14(1):90-94.
doi: 10.4274/tjps.30592. Epub 2017 Apr 15.

Flavin Containing Monooxygenases and Metabolism of Xenobiotics

Rahman Başaran  1 , Benay Can Eke  1
Affiliations
Review

Flavin Containing Monooxygenases and Metabolism of Xenobiotics

Rahman Başaran et al. Turk J Pharm Sci. 2017 Apr.

Abstract

This review summarizes recent information concerning the pharmacological and toxicological significance of the flavin-containing monooxygenases (FMOs). FMOs are a family of microsomal enzymes involving in the oxygenation of certain xenobiotics and drugs containing nucleophilic heteroatoms. The activities of FMOs in drug metabolism and their relationships with diseases are the areas of research requiring further exploration. Future studies on FMOs may provide considerable information about the pathophysiology of diseases and the information related to this enzyme family may be important for drug designs in future.

Keywords: Flavin monooxygenase; microsomal enzymes; phase 1 reactions.

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Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Figures

Figure 1
Figure 1
Catalytic cycle of flavin-containing monooxygenases NADPH: Nicotinamide adenine dinucleotide phosphate, FAD: Flavin adenine dinucleotide
See this image and copyright information in PMC

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