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. 2020 May 12:2020:9038629.
doi: 10.1155/2020/9038629. eCollection 2020.

The Efficacy of Concentrated Growth Factor in the Healing of Alveolar Osteitis: A Clinical Study

Aqsa Kamal  1   2 , Basheer Salman  1 , Noor Hayati Abdul Razak  2 , Ali Al Qabbani  1 , A R Samsudin  1
Affiliations

The Efficacy of Concentrated Growth Factor in the Healing of Alveolar Osteitis: A Clinical Study

Aqsa Kamal et al. Int J Dent. .

Abstract

Background: A dry socket also referred to as alveolar osteitis (AO) is a common postoperative complication following tooth extraction, due to the disruption of the clot within the wound. This study aimed to evaluate the efficacy of concentrated growth factor (CGF) in the healing of alveolar osteitis following tooth extraction.

Methods: The study was conducted at University Dental Hospital Sharjah, UAE. Patients undergoing tooth extraction at the oral surgery clinic were advised to return immediately if they suffer from pain. Over the following first week after tooth extraction, patients who reported pain symptoms were recalled and all dry sockets were identified. The patients were divided into two groups. Group I patients received conventional treatment with socket curettage and saline irrigation only, while in group II CGF was inserted into the socket. Both groups were observed for pain score and quantification of granulation tissue formation.

Results: A total of 40 dry socket patients, aged between 18 and 60 years, from a total of 1,250 patients, were included in the study. 30 patients were given conventional treatment while another 10 patients were given CGF. Patients who received CGF had a pain score of 7-10 at presentation, and the pain score dropped to 0-3 on day 4 and further improved to 0-1 on day 7 (p = 0.001). Granulation tissue formation appeared in the conventional group I on day 7 while the CGF group II showed earlier granulation tissue formation by day 4 (p = 0.001). The posttreatment pain score is inversely proportional to the amount and rate of granulation tissue formation in the socket.

Conclusion: The study suggests that delivery of CGF into a dry socket helps relieve pain and expedite the wound healing process as shown by a statistically much lower pain score and earlier and more rapid formation of granulation tissue when compared to the conventional alveolar osteitis therapy.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this article.

Figures

Figure 1
Figure 1
Molecular mechanism of alveolar osteitis. Plasminogen type-1 is the precursor of plasmin which acts in fibrin degradation. Plasmin inhibitor sterically shields the active site of plasmin, thus substantially decreasing plasmin's access to protein substrates [15]. t-PA: tissue-type plasminogen activator; FDP: fibrin degradation products.
Figure 2
Figure 2
Visual analogue pain scale (VAS) for recording the pain level of patients for dry socket [30, 31].
See this image and copyright information in PMC

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