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Review
. 2020 May 10:2020:4965171.
doi: 10.1155/2020/4965171. eCollection 2020.

The Role of Antioxidants in Ameliorating Cyclophosphamide-Induced Cardiotoxicity

Muluken Altaye Ayza  1 , Kaleab Alemayehu Zewdie  1 , Bekalu Amare Tesfaye  1 , Dawit Zewdu Wondafrash  1 , Abera Hadgu Berhe  1
Affiliations
Review

The Role of Antioxidants in Ameliorating Cyclophosphamide-Induced Cardiotoxicity

Muluken Altaye Ayza et al. Oxid Med Cell Longev. .

Abstract

The chemotherapeutic and immunosuppressive agent cyclophosphamide has previously been shown to induce complications within the setting of bone marrow transplantation. More recently, cardiotoxicity has been shown to be a dose-limiting factor during cyclophosphamide therapy, and cardiooncology is getting wider attention. Though mechanism of cyclophosphamide-induced cardiotoxicity is not completely understood, it is thought to encompass oxidative and nitrative stress. As such, this review focuses on antioxidants and their role in preventing or ameliorating cyclophosphamide-induced cardiotoxicity. It will give special emphasis to the cardioprotective effects of natural, plant-derived antioxidants that have garnered significant interest in recent times.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Major metabolic pathway of cyclophosphamide.
Figure 2
Figure 2
Molecular mechanisms involved in cyclophosphamide-induced cardiotoxicity.
See this image and copyright information in PMC

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