Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Apr 6;5(2):101-105.
doi: 10.7150/jbji.42079. eCollection 2020.

Wound Complications after 2-Octyl Skin Closure Systems for Total Joint Arthroplasty

Andrew Michalowitz  1 , Robert Comrie  1 , Christopher Nicholas  1 , Michael Wagner  1 , James Kehoe  1
Affiliations

Wound Complications after 2-Octyl Skin Closure Systems for Total Joint Arthroplasty

Andrew Michalowitz et al. J Bone Jt Infect. .

Abstract

Introduction: Total joint arthroplasty is projected to expand rapidly by 2030. With large numbers of patients undergoing TJA, the choice of incisional closure has come into question. We compared the 2-Ocyl cyanoacrylate closure system of Dermabond ® Prineo ® with Exofin Fusion ® to compare rates of adverse wound outcomes after total joint arthroplasty. Secondary outcome measures were age, sex, and medical comorbidities between groups. Methods: We retrospectively reviewed adverse wound outcomes with skin closure in TJA in 281 patients (160 Dermabond Prineo and 121 Exofin Fusion). Clinical charts were analyzed out to the 6-week post-op visit. Results: The rate of overall adverse superficial wound outcomes was similar between the two groups with Dermabond Prineo (N=20) and Exofin Fusion (N=19). The rate of cellulitis was significantly higher for Dermabond Prineo when compared to Exofin Fusion (P=0.033). No other significant differences were found for rate of superficial or deep wound complications or for secondary outcomes. Conclusions: The two 2-octyl wound closure systems had similar adverse superficial wound complications. Except for Dermabond Prineo having a higher rate of post-operative cellulitis, there were no statistically significant differences for other superficial or deep adverse wound outcomes or secondary outcomes. A future randomized control trial or prospective cohort study is needed for a more robust analysis.

Keywords: 2-cyanoacrylate; 2-octyl; Dermabond; Exofin; Prineo; dermatitis; superficial infection; total joint arthroplasty.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

References

    1. Kurtz SM, Ong KL, Lao E. et al. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. Journal of Bone and Joint Surgery. 2007;89:780–785. - PubMed
    1. Kurtz SM, Ong KL, Lau E. et al. Prosthetic joint infection risk after TKA in the Medicare population. Clinical and Orthopedic Related Research. 2010;468:52–56. - PMC - PubMed
    1. Carroll K, Dowsey M, Choong P. et al. Risk factors for superficial wound complications in hip and knee arthroplasty. Clinical Microbiology and Infections. 2013;20:130–135. - PubMed
    1. Guirro P, Hinarejos P, Pelfort X. et al. Long term follow-up of successfully treated superficial wound infections following TKA. The Journal of Arthroplasty. 2015;30:101–103. - PubMed
    1. Ethicon. Dermabond Prineo Skin Closure Systems Discussion Guide. Ethicon Endo-Surgery (Europe). Revised May. 2017. GmbH Hummelsbütteler Steindamm 71 22851 Norderstedt, Germany.