Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2020 May 21;21(10):3645.
doi: 10.3390/ijms21103645.

Melatonin from an Antioxidant to a Classic Hormone or a Tissue Factor: Experimental and Clinical Aspects 2019

Juan C Mayo  1   2 , Rosa M Sainz  1   2
Affiliations
Editorial

Melatonin from an Antioxidant to a Classic Hormone or a Tissue Factor: Experimental and Clinical Aspects 2019

Juan C Mayo et al. Int J Mol Sci. .

Abstract

During the last 25 years we have accomplished great advances in melatonin research, regarding antioxidant or anti-inflammatory functions, oncostatic actions, glucose metabolism regulation or plant physiology, among others. Of course, we should not forget the classical, circadian-related functions of the indole, which has recently brought up new and important findings. All together these new discoveries will likely lead the way in the next decade in terms of melatonin research. This special issue collects some of these new advances focused on different aspects of the indole.

Keywords: anti-cancer; anti-depressant; antioxidant; melanoma; melatonin; neurogenesis; pineal gland; plant physiology; preterm infants.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Tan D.-X. Melatonin a potent endogenous hydroxyl radical scavenger. Endocrine. 1993;1:57–60.
    1. Reiter R.J., Mayo J.C., Tan D.X., Sainz R.M., Alatorre-Jimenez M., Qin L. Melatonin as an antioxidant: Under promises but over delivers. J. Pineal Res. 2016:253–278. doi: 10.1111/jpi.12360. - DOI - PubMed
    1. Mayo J.C., Sainz R.M., Tan D.X., Hardeland R., Leon J., Rodriguez C., Reiter R.J. Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages. J. Neuroimmunol. 2005;165:139–149. doi: 10.1016/j.jneuroim.2005.05.002. - DOI - PubMed
    1. Hardeland R. Melatonin and inflammation-Story of a double-edged blade. J. Pineal Res. 2018;65:e12525. doi: 10.1111/jpi.12525. - DOI - PubMed
    1. Di Bella G., Mascia F., Gualano L., Di Bella L. Melatonin anticancer effects: Review. Int. J. Mol. Sci. 2013;14:2410–2430. doi: 10.3390/ijms14022410. - DOI - PMC - PubMed

Publication types

LinkOut - more resources