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Review
. 2020 May 22;9(5):1293.
doi: 10.3390/cells9051293.

Blood and Cancer: Cancer Stem Cells as Origin of Hematopoietic Cells in Solid Tumor Microenvironments

Ghmkin Hassan  1   2 , Masaharu Seno  1
Affiliations
Review

Blood and Cancer: Cancer Stem Cells as Origin of Hematopoietic Cells in Solid Tumor Microenvironments

Ghmkin Hassan et al. Cells. .

Abstract

The concepts of hematopoiesis and the generation of blood and immune cells from hematopoietic stem cells are some steady concepts in the field of hematology. However, the knowledge of hematopoietic cells arising from solid tumor cancer stem cells is novel. In the solid tumor microenvironment, hematopoietic cells play pivotal roles in tumor growth and progression. Recent studies have reported that solid tumor cancer cells or cancer stem cells could differentiate into hematopoietic cells. Here, we discuss efforts and research that focused on the presence of hematopoietic cells in tumor microenvironments. We also discuss hematopoiesis from solid tumor cancer stem cells and clarify the notion of differentiation of solid tumor cancer stem cells into non-cancer hematopoietic stem cells.

Keywords: cancer stem cells; hematopoietic cells; tumor microenvironments.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic illustration of tumor microenvironment showing different cell phenotypes including different hematopoietic cells.
Figure 2
Figure 2
Schematic illustration of some types of hematopoietic cells in the tumor microenvironment that either support or suppress tumor growth. TAM, tumor-associated macrophages; MDSC, myeloid-derived suppressor cells; TIDC, tumor-infiltrating dendritic cell; T cells, T lymphocyte; DC, dendritic cell; M1, M1 macrophage; NK, natural killer cell.
See this image and copyright information in PMC

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