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. 2020 May 23;17(10):3679.
doi: 10.3390/ijerph17103679.

Association Between Gout and Injury Risk: A National Retrospective Cohort Study

Shih-Hsiang Ou  1 , Chu-Lin Chou  2   3 , Chia-Wei Lin  4 , Wu-Chien Chien  5 , Te-Chao Fang  3   6 , Kuo-Cheng Lu  7   8 , Jin-Shuen Chen  9   10
Affiliations

Association Between Gout and Injury Risk: A National Retrospective Cohort Study

Shih-Hsiang Ou et al. Int J Environ Res Public Health. .

Abstract

The association between gout and injury remains unclear. This study aimed to investigate the injury risk in patients with gout. Using the Longitudinal Health Insurance Database (LHID) from 2000 to 2010 in Taiwan, patients with gout (group CFG) and those without gout (group C) were enrolled for further analysis. The CFG group was separated into two subgroups (with and without medication) to determine whether the risk of injury was reduced with drug intervention. The follow-up period was defined as the time from the initial diagnosis of gout to the date of injury. A total of 257,442 individuals were enrolled in this study, with 85,814 people in group CFG and 171,628 people in group C. Using Cox regression analysis, group CFG showed a significant increase in the risk of injury. Traffic injuries, poisoning, falls, crushing/cutting/piercing injury, and suicides were prominent among these injuries. Furthermore, when urate-lowing drugs were used to treat the CFG group, there were no significant differences in the occurrence of injury. Patients with gout had an increased risk of injury overall, and drug intervention did not lower the risk of injury in these patients.

Keywords: gout; injury; urate-lowering therapy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Kaplan–Meier analysis for cumulative risk of injury among patients aged 18 and over stratified by gout with log-rank test.
Figure 2
Figure 2
Kaplan–Meier analysis for (A) cumulative risk of injury among patients with gout and over, stratified by intervention of medications with the log-rank test and (B) cumulative risk of injury among patients with gout and over, stratified by adherence of medications (MPR) with the log-rank test.
See this image and copyright information in PMC

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