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Clinical Trial
. 1977 May 14;1(6071):1254-6.
doi: 10.1136/bmj.1.6071.1254.

Prophylactic use of cephazolin against wound sepsis after cholecystectomy

C J Strachan, J Black, S J Powis, T A Waterworth, R Wise, A R Wilkinson, D W Burdon, M Severn, B Mitra, H Norcott
Clinical Trial

Prophylactic use of cephazolin against wound sepsis after cholecystectomy

C J Strachan et al. Br Med J. .

Abstract

A trial of antibiotic prophylaxis with cephazolin against postoperative wound sepsis was carried out on 201 patients undergoing routine cholecystectomy. Wound sepsis occurred in 11 out of 65 controls (16.9%), who were not given the drug; two out of 63 patients (3.2%) given a single dose preoperatively; and four out of 73 patients (5.5%) given the single preoperative dose plus a five-day course postoperatively. The difference between the controls and patients given the single preoperative dose was significant.

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