Active tuberculosis, sequelae and COVID-19 co-infection: first cohort of 49 cases

Marina Tadolini^{1

2}, Luigi Ruffo Codecasa^{3

2}, José-María García-García⁴, François-Xavier Blanc⁵, Sergey Borisov⁶, Jan-Willem Alffenaar^{7

8

9}, Claire Andréjak¹⁰, Pierre Bachez¹¹, Pierre-Alexandre Bart¹², Evgeny Belilovski⁶, José Cardoso-Landivar¹³, Rosella Centis¹⁴, Lia D'Ambrosio¹⁵, María- Luiza De Souza-Galvão¹³, Angel Dominguez-Castellano¹⁶, Samir Dourmane¹⁷, Mathilde Fréchet Jachym¹⁸, Antoine Froissart¹⁹, Vania Giacomet²⁰, Delia Goletti²¹, Soazic Grard²², Gina Gualano²³, Armine Izadifar²⁴, Damien Le Du¹⁸, Margarita Marín Royo²⁵, Jesica Mazza-Stalder²⁶, Ilaria Motta²⁷, Catherine Wei Min Ong^{28

29}, Fabrizio Palmieri²³, Frédéric Rivière³⁰, Teresa Rodrigo⁴, Denise Rossato Silva³¹, Adrián Sánchez-Montalvá^{32

33

34}, Matteo Saporiti³, Paolo Scarpellini³⁵, Frédéric Schlemmer³⁶, Antonio Spanevello^{37

38}, Elena Sumarokova⁶, Eva Tabernero³⁹, Paul Anantharajah Tambyah^{28

29}, Simon Tiberi^{40

41}, Alessandro Torre⁴², Dina Visca^{37

38}, Miguel Zabaleta Murguiondo⁴³, Giovanni Sotgiu⁴⁴, Giovanni Battista Migliori⁴⁵

Affiliations

¹ Unit of Infectious Diseases, Dept of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
² Co-first authors.
³ TB Reference Centre, Villa Marelli Institute, Niguarda Hospital, Milan, Italy.
⁴ Tuberculosis Research Programme (PII-TB), SEPAR, Barcelona, Spain.
⁵ Centre Hospitalier Universitaire, Nantes, France.
⁶ Moscow Research and Clinical Center for TB Control, Moscow, Russian Federation.
⁷ The University of Sydney, Sydney Pharmacy School, Sydney, Australia.
⁸ Westmead Hospital, Sydney, Australia.
⁹ Marie Bashir Institute of Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia.
¹⁰ Service de Pneumologie CHU AMIENS PICARDIE, France AND UR Université de Picardie Jules Verne, Amiens, France.
¹¹ Service de Pneumologie, Clinique Saint Luc, Bouge, Belgium.
¹² Dept of Internal Medicine, Lausanne University, Lausanne, Switzerland.
¹³ Servicio Neumología, Vall D´Hebron University Hospital, Barcelona, Spain.
¹⁴ Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy.
¹⁵ Public Health Consulting Group, Lugano, Switzerland.
¹⁶ Servicio de Enfermedades Infecciosas y Microbiología, Hospital Virgen Macarena, Sevilla, Spain.
¹⁷ Service de Pneumologie, Groupe hospitalier sud île de France (GHSIF), Melun, France.
¹⁸ Centre Hospitalier de Bligny, Briis Sous Forges, France.
¹⁹ Service de Médecine interne, CHI de Créteil, Créteil, France.
²⁰ Pediatric Infectious Diseases Unit, Dept of Biomedical and Clinical Sciences, L. Sacco Hospital, University of Milan, Milan, Italy.
²¹ Translational Research Unit, National Institute for Infectious Diseases 'L. Spallanzani', IRCCS, Rome, Italy.
²² Centre de Lutte Antituberculeuse (CLAT 38), Grenoble, France.
²³ Respiratory Infectious Diseases Unit, National Institute for Infectious Diseases 'L. Spallanzani', IRCCS, Rome, Italy.
²⁴ Hôpital Européen de Paris La Roseraie, Aubervilliers, France.
²⁵ Servicio Neumología, Hospital General Universitario de Castellón, Castelló, Spain.
²⁶ Pulmonary Division, Lausanne University Hospital CHUV, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
²⁷ Dipartimento di Scienze Mediche, Clinica Universitaria Malattie Infettive, Ospedale Amedeo di Savoia, Torino, Italia.
²⁸ Dept of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
²⁹ Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore.
³⁰ Hôpital d'Instruction des Armées (HIA) Percy, Clamart, France.
³¹ Faculdade de Medicina, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, Brazil.
³² Infectious Diseases Dept, International Health and Tuberculosis Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
³³ Vall d'Hebron Institute of Research (VHIR), Barcelona, Spain.
³⁴ Grupo de Estudio de Infecciones por Micobacterias (GEIM), Spanish Society of Infectious Diseases (SEIMC), Spain.
³⁵ Unit of Infectious Diseases, Università Vita e Salute, San Raffaele Hospital, Milan, Italy.
³⁶ Hôpitaux Universitaires Henri Mondor, AP-HP, Créteil, France.
³⁷ Division of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri, IRCCS, Tradate, Italy.
³⁸ Dept of Medicine and Surgery, Respiratory Diseases, University of Insubria, Tradate, Italy.
³⁹ Servicio Neumología, Hospital de Cruces, Bilbao, Spain.
⁴⁰ Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
⁴¹ Division of Infection, Royal London Hospital, Barts Health NHS Trust, London, UK.
⁴² Dept of Infectious Diseases, University of Milan, L. Sacco Hospital, Milan, Italy.
⁴³ Servicio Neumología Hospital Universitario Marqués de Valdecilla, Santander, Spain.
⁴⁴ Clinical Epidemiology and Medical Statistics Unit, Dept of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
⁴⁵ Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy giovannibattista.migliori@icsmaugeri.it.

PMID: 32457198
PMCID: PMC7251245
DOI: 10.1183/13993003.01398-2020

Active tuberculosis, sequelae and COVID-19 co-infection: first cohort of 49 cases

Marina Tadolini et al. Eur Respir J. 2020.

. 2020 Jul 9;56(1):2001398.

doi: 10.1183/13993003.01398-2020. Print 2020 Jul.

Authors

Affiliations

¹ Unit of Infectious Diseases, Dept of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
² Co-first authors.
³ TB Reference Centre, Villa Marelli Institute, Niguarda Hospital, Milan, Italy.
⁴ Tuberculosis Research Programme (PII-TB), SEPAR, Barcelona, Spain.
⁵ Centre Hospitalier Universitaire, Nantes, France.
⁶ Moscow Research and Clinical Center for TB Control, Moscow, Russian Federation.
⁷ The University of Sydney, Sydney Pharmacy School, Sydney, Australia.
⁸ Westmead Hospital, Sydney, Australia.
⁹ Marie Bashir Institute of Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia.
¹⁰ Service de Pneumologie CHU AMIENS PICARDIE, France AND UR Université de Picardie Jules Verne, Amiens, France.
¹¹ Service de Pneumologie, Clinique Saint Luc, Bouge, Belgium.
¹² Dept of Internal Medicine, Lausanne University, Lausanne, Switzerland.
¹³ Servicio Neumología, Vall D´Hebron University Hospital, Barcelona, Spain.
¹⁴ Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy.
¹⁵ Public Health Consulting Group, Lugano, Switzerland.
¹⁶ Servicio de Enfermedades Infecciosas y Microbiología, Hospital Virgen Macarena, Sevilla, Spain.
¹⁷ Service de Pneumologie, Groupe hospitalier sud île de France (GHSIF), Melun, France.
¹⁸ Centre Hospitalier de Bligny, Briis Sous Forges, France.
¹⁹ Service de Médecine interne, CHI de Créteil, Créteil, France.
²⁰ Pediatric Infectious Diseases Unit, Dept of Biomedical and Clinical Sciences, L. Sacco Hospital, University of Milan, Milan, Italy.
²¹ Translational Research Unit, National Institute for Infectious Diseases 'L. Spallanzani', IRCCS, Rome, Italy.
²² Centre de Lutte Antituberculeuse (CLAT 38), Grenoble, France.
²³ Respiratory Infectious Diseases Unit, National Institute for Infectious Diseases 'L. Spallanzani', IRCCS, Rome, Italy.
²⁴ Hôpital Européen de Paris La Roseraie, Aubervilliers, France.
²⁵ Servicio Neumología, Hospital General Universitario de Castellón, Castelló, Spain.
²⁶ Pulmonary Division, Lausanne University Hospital CHUV, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
²⁷ Dipartimento di Scienze Mediche, Clinica Universitaria Malattie Infettive, Ospedale Amedeo di Savoia, Torino, Italia.
²⁸ Dept of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
²⁹ Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore.
³⁰ Hôpital d'Instruction des Armées (HIA) Percy, Clamart, France.
³¹ Faculdade de Medicina, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, Brazil.
³² Infectious Diseases Dept, International Health and Tuberculosis Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
³³ Vall d'Hebron Institute of Research (VHIR), Barcelona, Spain.
³⁴ Grupo de Estudio de Infecciones por Micobacterias (GEIM), Spanish Society of Infectious Diseases (SEIMC), Spain.
³⁵ Unit of Infectious Diseases, Università Vita e Salute, San Raffaele Hospital, Milan, Italy.
³⁶ Hôpitaux Universitaires Henri Mondor, AP-HP, Créteil, France.
³⁷ Division of Pulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri, IRCCS, Tradate, Italy.
³⁸ Dept of Medicine and Surgery, Respiratory Diseases, University of Insubria, Tradate, Italy.
³⁹ Servicio Neumología, Hospital de Cruces, Bilbao, Spain.
⁴⁰ Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
⁴¹ Division of Infection, Royal London Hospital, Barts Health NHS Trust, London, UK.
⁴² Dept of Infectious Diseases, University of Milan, L. Sacco Hospital, Milan, Italy.
⁴³ Servicio Neumología Hospital Universitario Marqués de Valdecilla, Santander, Spain.
⁴⁴ Clinical Epidemiology and Medical Statistics Unit, Dept of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
⁴⁵ Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy giovannibattista.migliori@icsmaugeri.it.

PMID: 32457198
PMCID: PMC7251245
DOI: 10.1183/13993003.01398-2020

Abstract

Diagnostic, treatment and outcome details of 49 COVID-19 patients with concurrent or previous tuberculosis from 8 countries show varied clinical profiles https://bit.ly/369ZGGu

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: M. Tadolini has nothing to disclose. Conflict of interest: L.R. Codecasa has nothing to disclose. Conflict of interest: J-M. García-García has nothing to disclose. Conflict of interest: F-X. Blanc has nothing to disclose. Conflict of interest: S. Borisov has nothing to disclose. Conflict of interest: J-W. Alffenaar has nothing to disclose. Conflict of interest: C. Andréjak has nothing to disclose. Conflict of interest: P. Bachez has nothing to disclose. Conflict of interest: P-A. Bart has nothing to disclose. Conflict of interest: E. Belilovski has nothing to disclose. Conflict of interest: J. Cardoso-Landivar has nothing to disclose. Conflict of interest: R. Centis has nothing to disclose. Conflict of interest: L. D'Ambrosio has nothing to disclose. Conflict of interest: M-L. De Souza-Galvão has nothing to disclose. Conflict of interest: A. Dominguez-Castellano has nothing to disclose. Conflict of interest: S. Dourmane has nothing to disclose. Conflict of interest: M. Fréchet Jachym has nothing to disclose. Conflict of interest: A. Froissart has nothing to disclose. Conflict of interest: V. Giacomet has nothing to disclose. Conflict of interest: D. Goletti has nothing to disclose. Conflict of interest: S. Grard has nothing to disclose. Conflict of interest: G. Gualano has nothing to disclose. Conflict of interest: A. Izadifar has nothing to disclose. Conflict of interest: D. Le Du has nothing to disclose. Conflict of interest: M. Marín Royo has nothing to disclose. Conflict of interest: J. Mazza-Stalder has nothing to disclose. Conflict of interest: I. Motta has nothing to disclose. Conflict of interest: C.W.M. Ong has nothing to disclose. Conflict of interest: F. Palmieri has nothing to disclose. Conflict of interest: F. Rivière has nothing to disclose. Conflict of interest: T. Rodrigo has nothing to disclose. Conflict of interest: D.R. Silva has nothing to disclose. Conflict of interest: A. Sánchez-Montalvá has nothing to disclose. Conflict of interest: M. Saporiti has nothing to disclose. Conflict of interest: P. Scarpellini has nothing to disclose. Conflict of interest: F. Schlemmer has nothing to disclose. Conflict of interest: A. Spanevello has nothing to disclose. Conflict of interest: E. Sumarokova has nothing to disclose. Conflict of interest: E. Tabernero has nothing to disclose. Conflict of interest: P.A. Tambyah has nothing to disclose. Conflict of interest: S. Tiberi has nothing to disclose. Conflict of interest: A. Torre has nothing to disclose. Conflict of interest: D. Visca has nothing to disclose. Conflict of interest: M. Zabaleta Murguiondo has nothing to disclose. Conflict of interest: G. Sotgiu has nothing to disclose. Conflict of interest: G.B. Migliori has nothing to disclose.

Comment in

COVID-19, tuberculosis and poverty: preventing a perfect storm.
Saunders MJ, Evans CA. Saunders MJ, et al. Eur Respir J. 2020 Jul 9;56(1):2001348. doi: 10.1183/13993003.01348-2020. Print 2020 Jul. Eur Respir J. 2020. PMID: 32444399 Free PMC article.
The (in)significance of TB and COVID-19 co-infection.
Khurana AK, Aggarwal D. Khurana AK, et al. Eur Respir J. 2020 Aug 20;56(2):2002105. doi: 10.1183/13993003.02105-2020. Print 2020 Aug. Eur Respir J. 2020. PMID: 32554537 Free PMC article.
On tuberculosis and COVID-19 co-infection.
Tadolini M, García-García JM, Blanc FX, Borisov S, Goletti D, Motta I, Codecasa LR, Tiberi S, Sotgiu G, Migliori GB; GTN TB/COVID group. Tadolini M, et al. Eur Respir J. 2020 Aug 20;56(2):2002328. doi: 10.1183/13993003.02328-2020. Print 2020 Aug. Eur Respir J. 2020. PMID: 32586888 Free PMC article.
Impact of the SARS-CoV-2 epidemic on tuberculosis treatment outcome in Northern Italy.
Magro P, Formenti B, Marchese V, Gulletta M, Tomasoni LR, Caligaris S, Castelli F, Matteelli A. Magro P, et al. Eur Respir J. 2020 Oct 1;56(4):2002665. doi: 10.1183/13993003.02665-2020. Print 2020 Oct. Eur Respir J. 2020. PMID: 32703780 Free PMC article.
The impact of COVID-19 and the restoration of tuberculosis services in the Western Pacific Region.
Chiang CY, Islam T, Xu C, Chinnayah T, Garfin AMC, Rahevar K, Raviglione M. Chiang CY, et al. Eur Respir J. 2020 Oct 22;56(4):2003054. doi: 10.1183/13993003.03054-2020. Print 2020 Oct. Eur Respir J. 2020. PMID: 32978310 Free PMC article.
A profile of a retrospective cohort of 22 patients with COVID-19 and active/treated tuberculosis.
Gupta N, Ish P, Gupta A, Malhotra N, Caminero JA, Singla R, Kumar R, Yadav SR, Dev N, Agrawal S, Kohli S, Sen MK, Chakrabarti S, Gupta NK. Gupta N, et al. Eur Respir J. 2020 Nov 19;56(5):2003408. doi: 10.1183/13993003.03408-2020. Print 2020 Nov. Eur Respir J. 2020. PMID: 33093125 Free PMC article.

References

1. Worldometers COVID-19 Coronavirus Pandemic. www.worldometers.info/coronavirus Date last updated: April 23, 2020.
1. Vitacca M, Nava S, Santus P, et al. . Early consensus management for non-ICU ARF SARS-CoV-2 emergency in Italy: from ward to trenches. Eur Respir J 2020; 55: 2000632. doi:10.1183/13993003.00632-2020 - DOI - PMC - PubMed
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Active tuberculosis, sequelae and COVID-19 co-infection: first cohort of 49 cases

Affiliations

Active tuberculosis, sequelae and COVID-19 co-infection: first cohort of 49 cases

Authors

Affiliations

Abstract

Conflict of interest statement

Comment in

References

Publication types

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LinkOut - more resources

Full Text Sources

Miscellaneous