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. 2020 May 8:8:305.
doi: 10.3389/fcell.2020.00305. eCollection 2020.

Breathing New Life into the Mechanisms of Platinum Resistance in Lung Adenocarcinoma

Alvaro Gonzalez-Rajal  1 , Jordan F Hastings  2 , D Neil Watkins  3   4 , David R Croucher  2   5 , Andrew Burgess  1   6
Affiliations

Breathing New Life into the Mechanisms of Platinum Resistance in Lung Adenocarcinoma

Alvaro Gonzalez-Rajal et al. Front Cell Dev Biol. .
No abstract available

Keywords: DNA damage; DNA repair; TGF-β; cell cycle; cisplatin; follistatin; p21; p53.

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Figures

Figure 1
Figure 1
Overview of the recent mechanisms of resistance identified in lung adenocarcinoma. Briefly, mechanism of resistance work to increase repair of DNA damage and or prevent the triggering of cell death through inhibition of apoptotic signaling. Black solid arrows indicated activation. Red arrows indicate inhibition. Solid and dashed lines indicate direct and indirect mechanisms. Blue and orange stars indicate that loss (e.g., by RNAi, CRISPR, or chemical inhibition) confers sensitivity and resistance to cisplatin, respectively. Blue block arrow indicates potential therapeutic cisplatin synergistic treatment options. CISP, cisplatin; EMT, epithelial-mesenchymal transition; SSB/DSB, single/double strand breaks; FA, Fanconi Anemia pathway; ROS, reactive oxygen species; Cyto.C, Cytochrome C. The Figure created with BioRender.com.
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