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Review
. 2020 Jul;72(7):1322-1339.
doi: 10.1002/iub.2285. Epub 2020 May 26.

Current status and perspectives regarding the association between allergic disorders and cancer

Mohammad Fereidouni  1   2 , Gordon A Ferns  3 , Afsane Bahrami  2
Affiliations
Free article
Review

Current status and perspectives regarding the association between allergic disorders and cancer

Mohammad Fereidouni et al. IUBMB Life. 2020 Jul.
Free article

Abstract

While activation of immune system may lead to a lower risk of some diseases, it has been shown that a history of atopic allergic disorders such as asthma, hay fever, eczema, and food allergies could be related to several types of cancer. However, the evidence is not entirely conclusive. Two proposals suggest a possible mechanism for the association between allergic disorders and cancers: immune surveillance and the antigenic stimulation. The association of allergy and cancer may vary by cancer site and the type of exposure. The aim of current review was to summarize the current knowledge of the association between allergic diseases and the risk of cancers with particular emphasis on case-controls and cohort studies to estimate the cancer risk associated with allergy.

Keywords: allergy; asthma; atopy; cancer; rhinitis; tumor.

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References

REFERENCES

    1. Kidd P. Th1/Th2 balance: The hypothesis, its limitations, and implications for health and disease. Altern Med Rev. 2003;8:223-246.
    1. Feili-Hariri M, Falkner DH, Morel PA. Polarization of naive T cells into Th1 or Th2 by distinct cytokine-driven murine dendritic cell populations: Implications for immunotherapy. J Leukoc Biol. 2005;78:656-664.
    1. Pinto RA, Arredondo SM, Bono MR, Gaggero AA, Díaz PV. T helper 1/T helper 2 cytokine imbalance in respiratory syncytial virus infection is associated with increased endogenous plasma cortisol. Pediatrics. 2006;117:e878-e886.
    1. Matsuzaki J, Tsuji T, Imazeki I, Ikeda H, Nishimura T. Immunosteroid as a regulator for Th1/Th2 balance: Its possible role in autoimmune diseases. Autoimmunity. 2005;38:369-375.
    1. Wang H, Diepgen T. Is atopy a protective or a risk factor for cancer? A review of epidemiological studies. Allergy. 2005;60:1098-1111.

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