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. 2020 Jul;103(1):190-192.
doi: 10.4269/ajtmh.19-0906. Epub 2020 May 21.

Barrita Virus, a Novel Virus of the Patois Serogroup (Genus Orthobunyavirus; Family Peribunyaviridae)

Diana Fernández  1   2   3 , William Marciel de Souza  4 , Jesus A Silvas  1   2   3 , Eleanor R Deardorff  1   2   3 , Steven G Widen  5 , Jose G Estrada-Franco  6 , Scott C Weaver  1   2   3   7   8 , Marcio Nunes  9 , Patricia V Aguilar  1   2   3   8
Affiliations

Barrita Virus, a Novel Virus of the Patois Serogroup (Genus Orthobunyavirus; Family Peribunyaviridae)

Diana Fernández et al. Am J Trop Med Hyg. 2020 Jul.

Abstract

During ecological investigations for arboviruses conducted in coastal Chiapas, Mexico, in 2007, isolate MP1078 was obtained from a pool of Psorophora varipes mosquitoes. Based on antigenic characterization, this isolate was classified as a strain of Patois virus (PATV) (Orthobunyavirus genus, Peribunyaviridae family). Recently, we conducted nearly complete genome sequencing of this isolate to gain further insight into its genetic relationship with other members of the Patois serogroup. Based on the genetic characterization, we determined that MP1078 contains S, M, and L genome segments that are genetically distinct from other viruses within the Patois serogroup. Serological analyses confirmed the taxonomic classification of MP1078 as a new virus and species within the Patois serogroup, and we propose the name Barrita virus (BITV).

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Figures

Figure 1.
Figure 1.
Maximum likelihood phylogenetic relationship of Patois serogroup viruses with other orthobunyaviruses. (A) S segment based on TMP2+F+G4 nucleotide substitution model. (B) M segment based on GTR+F+I+G4 nucleotide substitution model. (C) L segment based on TIM2+F+I+G4 nucleotide substitution model. Phylogenies are midpoint rooted and with proportional branches for clarity of presentation. The scale bar indicates the evolutionary distance in number of substitutions per amino acid substitutions/site, and the principal bootstrap support levels were indicated. The arrows indicate the position of the Patois-like MP1078 strain (Barrita virus).
Figure 2.
Figure 2.
P-distance analysis of Barrita virus within the members of Patois serogroup. Distance based on the S segment (left panel), M segment (middle panel), and L segment (right panel) are shown. Distances in the nucleotide level are showed in purple and the amino acids level in green. Barrita and Zegla viruses share 95.5% amino acid sequence identity in the L protein (depicted as 96% in the figure). This figure appears in color at www.ajtmh.org.
See this image and copyright information in PMC

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