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. 2020 Aug 1;156(8):844-853.
doi: 10.1001/jamadermatol.2020.1422.

Assessment of Overall and Specific Cancer Risks in Patients With Hidradenitis Suppurativa

Joon Min Jung  1 , Keon Hee Lee  1 , Ye-Jee Kim  2 , Sung Eun Chang  1 , Mi Woo Lee  1 , Jee Ho Choi  1 , Chong Hyun Won  1 , Woo Jin Lee  1
Affiliations

Assessment of Overall and Specific Cancer Risks in Patients With Hidradenitis Suppurativa

Joon Min Jung et al. JAMA Dermatol. .

Abstract

Importance: Large population-based studies investigating the risks of overall and specific cancers among patients with hidradenitis suppurativa (HS) are limited.

Objective: To assess the overall and specific cancer risks in patients with HS compared with the risks in patients without HS in the Republic of Korea.

Design, setting, and participants: A nationwide population-based cohort study, using the Korean Health Insurance Review and Assessment Service database was conducted over a 2-year period from January 1, 2007, to December 31, 2008. Individuals in the control group who were never diagnosed with HS or cancer during the washout period were randomly extracted and matched by age, sex, index year, and insurance type at a case-control ratio of 1:8, and patients with newly diagnosed HS between January 1, 2009, and December 31, 2017, were included. Follow-up data on incident cancer from January 1, 2009, to December 31, 2018, were included.

Main outcomes and measures: The overall and specific cancer incidence rates were calculated per 100 000 person-years in patients with HS and in the matched control cohort. The risk for cancers was assessed by multivariable Cox regression models in patients with HS compared with the matched control cohort.

Results: In total, 22 468 patients with HS and 179 734 matched controls were included in the study. The mean (SD) age was 33.63 (17.61) years and 63.7% of the participants in both groups were male. The adjusted hazard ratio (aHR) of overall cancer in patients with HS was 1.28 (95% CI, 1.15-1.42). Patients with HS had significantly higher risk for Hodgkin lymphoma (aHR, 5.08; 95% CI, 1.21-21.36), oral cavity and pharyngeal cancer (aHR, 3.10; 95% CI, 1.60-6.02), central nervous system cancer (aHR, 2.40; 95% CI, 1.22-4.70), nonmelanoma skin cancer (HR, 2.06; 95% CI, 1.12-3.79), prostate cancer (aHR, 2.05; 95% CI, 1.30-3.24), and colorectal cancer (aHR, 1.45; 95% CI, 1.09-1.93).

Conclusions and relevance: In this study, HS appeared to be associated with a significantly increased risk of overall cancer as well as several specific cancers.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Figures

Figure.
Figure.. Overall and Specific Cancer Risks in Patients With Hidradenitis Suppurativa Compared With a Matched Control Cohort
HR indicates hazard ratio. aIncidence rate per 100 000 person-years. bAdjusted for the presence of hypertension and dyslipidemia.
See this image and copyright information in PMC

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