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Review
. 2020 Jun;135(6):1270-1274.
doi: 10.1097/AOG.0000000000003864.

Ovarian Cancer After Prophylactic Salpingectomy in a Patient With Germline BRCA1 Mutation

Nicole Lugo Santiago  1 , Evan Smith, Mary Cox, Carrie S Wan, Nana E Tchabo, Ibraheem Awowole, Vance Broach, Dennis S Chi
Affiliations
Review

Ovarian Cancer After Prophylactic Salpingectomy in a Patient With Germline BRCA1 Mutation

Nicole Lugo Santiago et al. Obstet Gynecol. 2020 Jun.

Erratum in

Abstract

Background: Women with germline BRCA1 or BRCA2 mutations have a lifetime risk of ovarian cancer of up to 46%. Opportunistic salpingectomy has been advocated as a risk-reducing strategy owing to increasing recognition of tubal origin, yet evidence of efficacy in this high-risk population is limited.

Case: This is the case of a woman with a BRCA1 mutation who underwent prophylactic mastectomy and bilateral salpingectomy with ovarian retention before the age of 40 years. She did not undergo oophorectomy and subsequently developed stage IV high-grade serous ovarian cancer 4 years after her initial surgery.

Conclusion: More research is needed to determine the role of prophylactic salpingectomy with delayed oophorectomy, optimal timing of completion oophorectomy, and the risks and benefits compared with up-front risk-reducing salpingo-oophorectomy.

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Conflict of interest statement

Financial Disclosure:

Outside the submitted work, Dr. Chi reports personal fees from Bovie Medical Co. (Medical Advisory Board and stock options), Apyx Medical Corp. (Medical Advisory Board and stock options), C Surgeries (shareholder), and Biom ‘Up, (Medical Advisory Board). The other authors did not report any potential conflicts of interest.

Figures

Figure 1:
Figure 1:
Axial contrast-enhanced computed tomography image shows bilateral complex cystic and solid adnexal masses (white arrows). Peritoneal thickening and nodularity are also noted (black arrow).
Figure 2:
Figure 2:
Coronal contrast-enhanced computed tomography image. Black arrow indicates hepatic dome capsular implant with mass effect on the liver parenchyma. The adnexal masses are also visible (white arrows).
Figure 3:
Figure 3:
Sagittal computed tomography image. Black arrow indicates mildly enlarged right supradiaphragmatic lymph node. The hepatic capsular implant is also visible (white arrow).
See this image and copyright information in PMC

Comment in

  • Too Good to Be True.
    Jorgensen K, Schorge JO. Jorgensen K, et al. Obstet Gynecol. 2020 Jun;135(6):1267-1269. doi: 10.1097/AOG.0000000000003916. Obstet Gynecol. 2020. PMID: 32459416 No abstract available.

References

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