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Comment
. 2020 Jun;6(6):443-444.
doi: 10.1016/j.trecan.2020.02.018. Epub 2020 Mar 13.

PD1 Blockade in Cancer: Impact on Myeloid Cells

Mai Fujiwara  1 , Lucien P Garo  1 , Gopal Murugaiyan  2
Affiliations
Comment

PD1 Blockade in Cancer: Impact on Myeloid Cells

Mai Fujiwara et al. Trends Cancer. 2020 Jun.

Abstract

Programmed death 1 (PD1) has emerged as a major inhibitor of antitumor T cells, and anti-PD1 therapies have demonstrated clinical efficacy in multiple cancers. However, the impact of PD1 on other immune cells had remained unclear. A recent study by Strauss et al. describes how myeloid cell-intrinsic PD1 signaling limits myelopoiesis in cancer pertinent to anti-PD1 therapies.

Keywords: PD1; T cells; antitumor immunity; dendritic cells (DCs); myeloid cells; myeloid-derived suppressor cells (MDSCs).

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