Effect of cognitive rehabilitation on neuropsychological and semiecological testing and on daily cognitive functioning in multiple sclerosis: The REACTIV randomized controlled study
- PMID: 32460145
- DOI: 10.1016/j.jns.2020.116929
Effect of cognitive rehabilitation on neuropsychological and semiecological testing and on daily cognitive functioning in multiple sclerosis: The REACTIV randomized controlled study
Abstract
Background: Specific cognitive rehabilitation (SCR) has been suggested for multiple sclerosis (MS). A randomized controlled trial (RCT) evaluating the therapeutic effects of SCR is necessary.
Objective: To demonstrate the superiority of a SCR program (REACTIV) over nonspecific intervention (NSI) for neuropsychological (NP) assessment, virtual reality (VR) cognitive testing and daily cognitive functioning.
Methods: A single-blind RCT compared SCR and NSI in patients with MS with cognitive complaint. Both programs included 50 individual sessions, 3 times a week for 17 weeks in a real-world setting. The primary end-point was NP assessment. Secondary end-points included semiecological VR tasks (Urban Daily Cog®) and daily cognitive functioning assessment. Maintenance of the effects at 8 months was studied.
Results: Of the 35 patients, 18 completed the SCR, and 17 completed the NSI. Several NP and semiecological scores improved significantly more after SCR than after NSI. More NP scores improved significantly after SCR than after NSI. SCR improved daily cognitive functioning. Most improvements were maintained at 8 months.
Conclusion: SCR performed in a real-world setting is superior to NSI for improving performance in specific cognitive domains and information processing speed, and for improving cognitive functioning, as evaluated by ecological tools close to daily life and a daily cognitive functioning questionnaire.
Keywords: Clinical trial; Cognition; Cognitive rehabilitation; Information processing speed; Multiple sclerosis; Virtual reality.
Copyright © 2020 Elsevier B.V. All rights reserved.
Conflict of interest statement
Declaration of Competing Interest None.
Similar articles
-
Exploring the Potential of Immersive Virtual Reality (VR) as a tool to enhance cognitive functions and alleviate clinical symptoms in Multiple Sclerosis (MS): Enhancing Cognitive Functions in Multiple Sclerosis Using Virtual Reality.Mult Scler Relat Disord. 2025 Jan;93:106235. doi: 10.1016/j.msard.2024.106235. Epub 2024 Dec 17. Mult Scler Relat Disord. 2025. PMID: 39721210
-
Integrative group-based cognitive rehabilitation efficacy in multiple sclerosis: a randomized clinical trial.Disabil Rehabil. 2018 Jan;40(2):208-216. doi: 10.1080/09638288.2016.1250168. Epub 2016 Dec 7. Disabil Rehabil. 2018. PMID: 27927036 Clinical Trial.
-
Capturing cognitive changes in multiple sclerosis by performance-based functional and virtual reality assessments.Ann Phys Rehabil Med. 2023 Apr;66(3):101677. doi: 10.1016/j.rehab.2022.101677. Epub 2022 Nov 30. Ann Phys Rehabil Med. 2023. PMID: 35667625 Review.
-
Cognitive recovery in people with relapsing/remitting multiple sclerosis: A randomized clinical trial on virtual reality-based neurorehabilitation.Clin Neurol Neurosurg. 2021 Sep;208:106828. doi: 10.1016/j.clineuro.2021.106828. Epub 2021 Jul 21. Clin Neurol Neurosurg. 2021. PMID: 34332269 Clinical Trial.
-
Cognitive assessment in patients with multiple sclerosis: From neuropsychological batteries to ecological tools.Ann Phys Rehabil Med. 2020 Mar;63(2):154-158. doi: 10.1016/j.rehab.2018.01.006. Epub 2018 Feb 17. Ann Phys Rehabil Med. 2020. PMID: 29462665 Review.
Cited by
-
Virtual Reality-Based Therapy Improves Fatigue, Impact, and Quality of Life in Patients with Multiple Sclerosis. A Systematic Review with a Meta-Analysis.Sensors (Basel). 2021 Nov 6;21(21):7389. doi: 10.3390/s21217389. Sensors (Basel). 2021. PMID: 34770694 Free PMC article.
-
Cognitive Rehabilitation in Multiple Sclerosis in the Period from 2013 and 2021: A Narrative Review.Brain Sci. 2021 Dec 30;12(1):55. doi: 10.3390/brainsci12010055. Brain Sci. 2021. PMID: 35053798 Free PMC article. Review.
-
Effect of virtual reality exercise on interventions for patients with Alzheimer's disease: A systematic review.Front Psychiatry. 2022 Nov 9;13:1062162. doi: 10.3389/fpsyt.2022.1062162. eCollection 2022. Front Psychiatry. 2022. PMID: 36440413 Free PMC article.
-
Virtual reality for multiple sclerosis rehabilitation.Cochrane Database Syst Rev. 2025 Jan 7;1(1):CD013834. doi: 10.1002/14651858.CD013834.pub2. Cochrane Database Syst Rev. 2025. PMID: 39775922
-
Exercise-based gaming in patients with multiple sclerosis: A systematic review and meta-analysis.Belitung Nurs J. 2024 Feb 28;10(1):1-14. doi: 10.33546/bnj.3006. eCollection 2024. Belitung Nurs J. 2024. PMID: 38425686 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous