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. 2020;25(4):309-313.
doi: 10.5863/1551-6776-25.4.309.

Fluorescence Imaging Using Indocyanine Green Dye in the Pediatric Population

Shabana Zainab Shafy, Mohammed Hakim, Susan Lynch, Lian Chen, Joseph D Tobias

Fluorescence Imaging Using Indocyanine Green Dye in the Pediatric Population

Shabana Zainab Shafy et al. J Pediatr Pharmacol Ther. 2020.

Abstract

Objectives: Fluorescence imaging using indocyanine green (ICG) allows for the intraoperative mapping of the vascular supply of various tissue beds. Although generally safe and effective, rare adverse effects have been reported including anaphylactoid reactions. The current study retrospectively reviewed our experience the intraoperative administration of ICG to pediatric patients.

Methods: The anesthetic records of patients who received ICG over a 2-year time period were retrospectively reviewed and demographic, surgical, and medication data retrieved. Objective intraoperative data before and after the administration of ICG were also recorded. These included heart rate, systolic and diastolic blood pressures, oxygen saturation, and peak inflating pressure.

Results: The study cohort included 100 patients with a median age of 12 years (9.5 ± 7.4 years) and the median weight being 44.5 kg (45.9 ± 36.9 kg). ICG was administered intravenously to all patients. In all cases, 2.5 mg/mL ICG solution was used, with a median dose of 1.1 mL (1.79 ± 1.8 mL). Eight patients received more than 1 dose of ICG, with no adverse respiratory or hemodynamic effects related to its use.

Conclusions: ICG fluorescence is an important imaging modality that can be safely used as an intraoperative adjunct to various surgical procedures in the pediatric population.

Keywords: anesthesia; fluorescent dye; indocyanine green; pediatric.

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Conflict of interest statement

Disclosure The authors declare no conflicts or financial interest in any product or service mentioned in the manuscript, including grants, equipment, medications, employment, gifts, and honoraria. The authors had full access to all data and take responsibility for the integrity and accuracy of the data analysis.

References

    1. Choy G, Choyke P, Libutti SK. Current advances in molecular imaging: noninvasive in vivo bioluminescent and fluorescent optical imaging in cancer research. Mol Imaging. 2003;2(4):303–312. - PubMed
    1. Frangioni JV. In vivo near-infrared fluorescence imaging. Curr Opin Chem Biol. 2003;7(5):626–634. - PubMed
    1. Hilderbrand SA, Weissleder R. Near-infrared fluorescence: application to in vivo molecular imaging. Curr Opin Chem Biol. 2010;14(1):71–79. - PubMed
    1. Esposito C, Turrà F, Del Conte F et al. Indocyanine green fluorescence lymphography: a new technique to perform lymphatic sparing laparoscopic palomo varicocelectomy in children. J Laparoendosc Adv Surg Tech A. 2019;29(4):564–567. - PubMed
    1. Kusaka T, Isobe K, Nagano K et al. Estimation of regional cerebral blood flow distribution in infants by near-infrared topography using indocyanine green. Neuroimage. 2001;13(5):944–952. - PubMed

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