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Review
. 2020 Apr 1;14(2):140-150.

Hemoglobinopathies in Iran: An Updated Review

Abolfazl Nasiri  1   2 , Zohreh Rahimi  2   3 , Asad Vaisi-Raygani  2   4
Affiliations
Review

Hemoglobinopathies in Iran: An Updated Review

Abolfazl Nasiri et al. Int J Hematol Oncol Stem Cell Res. .

Abstract

Hemoglobinopathies are the most common single gene disorders (monogenic disorders) in the world population. Due to specific position of Iran and the presence of multi-ethnic groups in the country, there are many varieties in the molecular genetics and clinical features of hemoglobinopathies in Iran. Hemoglobinopathies include structural variants, thalassemias, and hereditary persistence of fetal hemoglobin. In this review, we look at the common structural variants in various parts of the country along with their hematological and clinical characteristics. Also, we discuss about the burden of the thalassemias in the country, different types, complications, molecular defects and therapy.

Keywords: Hemoglobin D; Hemoglobin S; Hemoglobinopathies; Mutation; Thalassemia.

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Figures

Figure1
Figure1
Frequently deletional and non-deletional mutations involved α-thalassemia are presented in tree diagram    101 .
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