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Case Reports
. 2020 May 11:21:e00795.
doi: 10.1016/j.idcr.2020.e00795. eCollection 2020.

Cytomegalovirus-associated esophageal stricture as a manifestation of the immune reconstitution inflammatory syndrome

B S Mansfield  1   2 , M J Savage-Reid  3 , J Moyo  4 , C N Menezes  1   2
Affiliations
Case Reports

Cytomegalovirus-associated esophageal stricture as a manifestation of the immune reconstitution inflammatory syndrome

B S Mansfield et al. IDCases. .

Abstract

Cytomegalovirus (CMV) esophagitis is well described in immunocompromised individuals, however, esophageal stricture due to CMV is rare. CMV disease in the setting of the immune reconstitution inflammatory syndrome (IRIS) usually takes the form of an immune-recovery uveitis or retinitis. We describe a young female patient with HIV who developed an esophageal stricture due to CMV within 6 months of starting antiretroviral therapy (ART). The patient responded well to treatment which involved 14 days of intravenous ganciclovir and esophageal dilatation. This is the first description of a patient developing gastrointestinal cytomegalovirus disease as a manifestation of IRIS.

Keywords: Cytomegalovirus; Esophageal stricture; Immune reconstitution inflammatory syndrome.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
(A) Barium swallow showing distal esophageal stricture (B) H&E stain at 100x magnification (C) Immunohistochemical stains at 400x magnification.
See this image and copyright information in PMC

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