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Review
. 2020 May 26;31(4):453-456.
doi: 10.1515/revneuro-2020-0026.

The involvement of the central nervous system in patients with COVID-19

Kiarash Saleki  1 , Mohammad Banazadeh  1 , Amene Saghazadeh  1   2 , Nima Rezaei  2   3   4
Affiliations
Free article
Review

The involvement of the central nervous system in patients with COVID-19

Kiarash Saleki et al. Rev Neurosci. .
Free article

Abstract

Coronaviruses disease (COVID-19) has caused major outbreaks. A novel variant, SARS-CoV-2, is responsible for COVID-19 pandemic. Clinical presentations and pathological mechanisms of COVID-19 are broad. The respiratory aspect of the disease has been extensively researched. Emerging studies point out the possibility of the central nervous system (CNS) involvement by COVID-19. Here, we discuss the current evidence for CNS involvement in COVID-19 and highlight that the high pathogenicity of SARS-CoV-2 might be due to its neuroinvasive potential.

Keywords: ACE2; COVID-19; SARS-CoV-2; anosmia; central nervous system (CNS); coronavirus.

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