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Review
. 2020 May 28;16(5):e1008480.
doi: 10.1371/journal.ppat.1008480. eCollection 2020 May.

Effector specificity and function in Drosophila innate immunity: Getting AMPed and dropping Boms

Samuel J H Lin  1 , Lianne B Cohen  1 , Steven A Wasserman  1
Affiliations
Review

Effector specificity and function in Drosophila innate immunity: Getting AMPed and dropping Boms

Samuel J H Lin et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Specificity of Drosophila immune effectors.
A–D each depict effectors’ contribution to defense against a particular pathogen, as deduced from loss-of-function phenotypes. Thick lines represent strong phenotypes, and thin lines represent weaker phenotypes. The effector repertoires induced by Toll (A and B) and by Imd (C and D) are largely invariant, but the subset of effectors that mediate the response to a given challenge varies. (A) The Boms and Bbd are required for survival against the yeast C. glabrata [13,15,16]. (B) Boms, Bbd, Dso1,2, Drs, and Mtk are necessary for survival against the filamentous fungus Aspergillus fumigatus [14,16,17]. (C) A number of AMPs (Dro, Dpt, and Att) overlap in function in providing defense against the gram-negative bacterium Providencia burhodogranariea [14]. (D) Dpt is the sole essential mediator of defense against the gram-negative bacterium P. rettgeri [14,24]. AMP, antimicrobial peptide; Att, Attacin; Bbd, Bombardier; Boms, Bomanins; Dso1,2, Daisho1 and Daisho2; Dpt, Diptericin; Dro, Drosocin; Drs, Drosomycin; Mtk, Metchnikowin.
See this image and copyright information in PMC

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