Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2020 May 28;135(22):1922-1923.
doi: 10.1182/blood.2020005676.

Regulation of venous thrombosis by platelet protein S

Rinku Majumder  1
Affiliations
Comment

Regulation of venous thrombosis by platelet protein S

Rinku Majumder. Blood. .

Abstract

In this issue of Blood, Calzavarini et al solve the long-standing puzzle of the function of protein S (PS) that has been derived from platelets (PSplt) by showing that PSplt limits thrombin formation in large veins.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interest.

Conflict-of-interest disclosure: The author declares no competing financial interest.

Comment on

Similar articles

See all similar articles

Cited by

References

    1. Calzavarini S, Prince-Eladnani R, Saller F, et al. . Platelet protein S limits venous but not arterial thrombosis propensity by controlling coagulation in the thrombus. Blood. 2020;135(22):1969-1982. - PMC - PubMed
    1. Marlar RA, Neumann A. Neonatal purpura fulminans due to homozygous protein C or protein S deficiencies. Semin Thromb Hemost. 1990;16(4):299-309. - PubMed
    1. Schwarz HP, Fischer M, Hopmeier P, Batard MA, Griffin JH. Plasma protein S deficiency in familial thrombotic disease. Blood. 1984;64(6):1297-1300. - PubMed
    1. Dahlbäck B. Factor V and protein S as cofactors to activated protein C. Haematologica. 1997;82(1):91-95. - PubMed
    1. Ndonwi M, Broze G Jr. Protein S enhances the tissue factor pathway inhibitor inhibition of factor Xa but not its inhibition of factor VIIa-tissue factor. J Thromb Haemost. 2008;6(6):1044-1046. - PubMed