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Comment
. 2020 May 28;135(22):1927-1928.
doi: 10.1182/blood.2020005714.

Shaping clonal hematopoiesis

Daniel C Link  1
Affiliations
Comment

Shaping clonal hematopoiesis

Daniel C Link. Blood. .

Abstract

In this issue of Blood, Eskelund et al characterize clonal hematopoiesis in serial samples from persons with mantle cell lymphoma (MCL) undergoing frontline treatment, providing evidence that treatment plays an important role in the development of clonal hematopoiesis.

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Conflict of interest statement

Conflict-of-interest disclosure: The author declares no competing financial interests.

Conflict-of-interest disclosure: The author declares no competing financial interests.

Figures

None
Evolution of clonal hematopoiesis during treatment of persons with MCL. HSPCs acquire somatic mutations with aging, resulting in the production of a genetically heterogenous pool of HPSCs. Genotoxic stress induced by chemotherapy favors the selection of HSP-Cs carrying mutations of DNA damage response genes, such as TP53 and PPM1D (red cells). Auto-HCT induces replicative stress and potentially other stresses related to an altered bone marrow microenvironment. In this study, auto-HCT was associated with the selective expansion of HPSCs carrying DNTM3A R882 mutations (purple cells). During long-term follow-up, the existing clonal hematopoiesis was mostly stable.
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Comment on

References

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