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Review
. 2020 Aug;68(8):1631-1642.
doi: 10.1002/glia.23846. Epub 2020 May 28.

Regulatory function of microRNAs in microglia

Dora Brites  1   2
Affiliations
Review

Regulatory function of microRNAs in microglia

Dora Brites. Glia. 2020 Aug.

Abstract

Microglia are CNS-resident cells involved in immune surveillance and maintenance of intercellular homeostasis, while also contributing to neurologic pathologies. MicroRNAs (miRNAs) are a class of small (~22 nucleotides) single-stranded noncoding RNAs that participate in gene regulation at the post-transcriptional level. miRNAs typically bind to the untranslated region (3' UTR) of RNAs. It has been shown that miRNAs are important players in controlling inflammation and that their abnormal expression is linked to cancer and ageing, and to the onset and progression of neurodegenerative disease. Furthermore, miRNAs participate in intercellular trafficking. Thus, miRNAs are released from cells in a free form, bound to proteins or packaged within extracellular vesicles (EVs), exerting paracrine and long distance signaling. In this review, recent findings on the role of miRNAs as drivers of microglia phenotypic changes and their cotribution in neurological disease are addressed. MAIN POINTS: miRNAs have a key role in microglia function/dysfunction, polarization, and restoration. Microglia are both a source and recipient of extracellular vesicles (EVs) containing miRNAs. Extracellular miRNAs may be found as soluble (free and EV cargo) and protein complexes.

Keywords: extracellular vesicles; miRNAs; microglia; neurodegenerative diseases.

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References

REFERENCES

    1. Abels, E. R., Maas, S. L. N., Nieland, L., Wei, Z., Cheah, P. S., Tai, E., … Breakefield, X. O. (2019). Glioblastoma-associated microglia reprogramming is mediated by functional transfer of extracellular miR-21. Cell Reports, 28(12), 3105-3119 e3107.
    1. Adams, D., Gonzalez-Duarte, A., O'Riordan, W. D., Yang, C. C., Ueda, M., Kristen, A. V., … Suhr, O. B. (2018). Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis. The New England Journal of Medicine, 379(1), 11-21.
    1. Adlakha, Y. K., & Saini, N. (2014). Brain microRNAs and insights into biological functions and therapeutic potential of brain enriched miRNA-128. Molecular Cancer, 13, 33.
    1. Alles, J., Fehlmann, T., Fischer, U., Backes, C., Galata, V., Minet, M., … Meese, E. (2019). An estimate of the total number of true human miRNAs. Nucleic Acids Research, 47(7), 3353-3364.
    1. Ambros, V., & Ruvkun, G. (2018). Recent molecular genetic explorations of Caenorhabditis elegans MicroRNAs. Genetics, 209(3), 651-673.

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