Towards Precision Medicine: Inclusion of Sex and Gender Aspects in COVID-19 Clinical Studies-Acting Now before It Is Too Late-A Joint Call for Action

Evelyne Bischof^{1

2

3}, Sabine Oertelt-Prigione^{4

5}, Rosemary Morgan⁶, Sabra L Klein^{7

8}, The Sex And Gender In Covid Clinical Trials Working Group Sgc, Gender And Covid Working Group

Affiliations

¹ Department of Advanced Biomedical Sciences, Federico II University of Naples, Via Pansini, 5, 80131 Naples, Italy.
² School of Clinical Medicine, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
³ Women's Brain Project, 8357 Guntershausen, Switzerland.
⁴ Department of Primary and Community Care, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
⁵ Institute of Legal and Forensic Medicine, Charité-Universitätsmedizin, 10117 Berlin, Germany.
⁶ Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
⁷ W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
⁸ Department of Biochemistry and Molecular Biology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

Editorial

Evelyne Bischof et al. Int J Environ Res Public Health. 2020.

. 2020 May 25;17(10):3715.

doi: 10.3390/ijerph17103715.

Evelyne Bischof^{1

2

3}, Sabine Oertelt-Prigione^{4

5}, Rosemary Morgan⁶, Sabra L Klein^{7

8}, The Sex And Gender In Covid Clinical Trials Working Group Sgc, Gender And Covid Working Group

¹ Department of Advanced Biomedical Sciences, Federico II University of Naples, Via Pansini, 5, 80131 Naples, Italy.
² School of Clinical Medicine, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China.
³ Women's Brain Project, 8357 Guntershausen, Switzerland.
⁴ Department of Primary and Community Care, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
⁵ Institute of Legal and Forensic Medicine, Charité-Universitätsmedizin, 10117 Berlin, Germany.
⁶ Department of International Health, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
⁷ W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
⁸ Department of Biochemistry and Molecular Biology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

Abstract

The COVID-19 global pandemic is accelerating investigations for effective vaccines and repurposable validated therapeutics [...].

The authors declare no conflict of interest.

1. Leung C. Clinical features of deaths in the novel coronavirus epidemic in China. Rev. Med. Virol. 2020 doi: 10.1002/rmv.2103. - DOI - PMC - PubMed
1. Zhavoronkov A. Geroprotective and senoremediative strategies to reduce the comorbidity, infection rates, severity, and lethality in gerophilic and gerolavic infections. Aging (Albany NY) 2020 doi: 10.18632/aging.102988. - DOI - PMC - PubMed
1. Bischof E., Wolfe J., Klein S.L. Clinical trials for COVID-19 should include sex as a variable. J. Clin. Investig. 2020 doi: 10.1172/JCI139306. - DOI - PMC - PubMed
1. Bali S., Dhatt R., Lal A., Jama A., Van Daalen K., Sridhar D., Gender and COVID-19 Working Group. Women in Global Health, and Gender and COVID-19 Working Group Off the back burner: Diverse and gender—Inclusive decision—Making for COVID-19 response and recovery. BMJ Glob. Health. 2020;5:e002595. doi: 10.1136/bmjgh-2020-002595. - DOI - PMC - PubMed
1. Klein S.L., Flanagan K.L. Sex differences in immune responses. Nat. Rev. Immunol. 2016 doi: 10.1038/nri.2016.90. - DOI - PubMed