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Randomized Controlled Trial
. 2020 May 25;12(5):1540.
doi: 10.3390/nu12051540.

Taurine Supplementation Increases Post-Exercise Lipid Oxidation at Moderate Intensity in Fasted Healthy Males

Milena Barbon de Carvalho  1 , Camila Fernanda Cunha Brandao  2   3 , Priscila Giacomo Fassini  3 , Thiago Mantello Bianco  4 , Gabriela Batitucci  1 , Bryan Steve Martinez Galan  1 , Flávia Giolo De Carvalho  5 , Tales Sambrano Vieira  1 , Eduardo Ferriolli  3 , Julio Sergio Marchini  3 , Adelino Sanchez Ramos da Silva  5 , Ellen Cristini de Freitas  1   5
Affiliations
Randomized Controlled Trial

Taurine Supplementation Increases Post-Exercise Lipid Oxidation at Moderate Intensity in Fasted Healthy Males

Milena Barbon de Carvalho et al. Nutrients. .

Abstract

Based on the fact that taurine can increase lipid metabolism, the objective of the present study was to evaluate the effects of different doses of acute taurine supplementation on lipid oxidation levels in healthy young men after a single bout of fasting aerobic exercise. A double-blind, acute, and crossover study design was conducted. Seventeen men (age 24.8 ± 4.07y; BMI: 23.9 ± 2.57 kg/m²) participated in the present study. Different doses of taurine (TAU) (3 g or 6 g) or placebo were supplemented 90 minutes before a single bout of fasting aerobic exercise (on a treadmill at 60% of VO2 max). The subjects performed three trials, and each one was separated by seven days. Blood samples were collected at baseline and after the exercise protocol of each test to analyze plasma levels of glycerol and taurine. Lipid and carbohydrate oxidation were determined immediately after exercise for 15 minutes by indirect calorimetry. We observed that TAU supplementation (6 g) increased lipid oxidation (38%) and reduced the respiratory coefficient (4%) when compared to the placebo (p < 0.05). However, no differences in lipid oxidation were observed between the different doses of taurine (3 g and 6 g). For glycerol concentrations, there were no differences between trials. Six grams of TAU supplementation 90 minutes before a single bout of aerobic exercise in a fasted state was sufficient to increase the lipid oxidation post-exercise in healthy young men.

Keywords: Aerobic exercise; fasting; fat oxidation; glycerol; supplementation; taurine.

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Conflict of interest statement

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1
Study design.
Figure 2
Figure 2
Substrate oxidation after the exercise session. RQ: Respiratory quotient; TAU 3 g: 3 g of taurine supplementation; TAU 6 g: 6 g of taurine supplementation. Symbol represents statistical difference (* p < 0.05, ** p < 0.01) by ANOVA one-way repeated measures.
Figure 3
Figure 3
Time-course changes in the oxygen uptake (VO2), carbon dioxide production (VCO2), respiratory quotient (RQ), lipid oxidation, and carbohydrate oxidation of TAU 3 g, placebo, and TAU 6 g groups. * Difference between TAU 6 g and placebo groups in the time of measures. Statistical difference (p < 0.05), by ANOVA two-way repeated measures (general linear model), post hoc Sidak for group*time interaction (respiratory quotient, lipid oxidation, and carbohydrate oxidation).
Figure 4
Figure 4
Main findings of the present investigation. Effect of the supplementation of different doses of taurine was evaluated following a bout of exercise in the fasted state, and it was observed that a moderate-intensity exercise session similarly increased lipolysis levels in all trials. Additionally, supplementation with 3 g increased taurine blood levels post-exercise when compared to placebo supplementation. The supplementation with 6 g increased taurine plasma levels and lipid oxidation, and decreased the respiratory quotient post-exercise when compared to placebo supplementation, and lipid oxidation was 27% higher than TAU 3 g (#), showing a greater impact on lipid oxidation than the 3 g in healthy young men.
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