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Editorial
. 2020 Jun 2;75(21):2661-2663.
doi: 10.1016/j.jacc.2020.04.017.

Lessons From MAVERICK-HCM: The Need for Less Speed

Jane E Wilcox  1 , Elizabeth M McNally  2
Affiliations
Editorial

Lessons From MAVERICK-HCM: The Need for Less Speed

Jane E Wilcox et al. J Am Coll Cardiol. .
No abstract available

Keywords: N-terminal pro-B-type natriuretic peptide (NT-proBNP); cardiac troponin I (cTnI); clinical study; hypertrophic cardiomyopathy; mavacamten.

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Comment on

  • Evaluation of Mavacamten in Symptomatic Patients With Nonobstructive Hypertrophic Cardiomyopathy.
    Ho CY, Mealiffe ME, Bach RG, Bhattacharya M, Choudhury L, Edelberg JM, Hegde SM, Jacoby D, Lakdawala NK, Lester SJ, Ma Y, Marian AJ, Nagueh SF, Owens A, Rader F, Saberi S, Sehnert AJ, Sherrid MV, Solomon SD, Wang A, Wever-Pinzon O, Wong TC, Heitner SB. Ho CY, et al. J Am Coll Cardiol. 2020 Jun 2;75(21):2649-2660. doi: 10.1016/j.jacc.2020.03.064. J Am Coll Cardiol. 2020. PMID: 32466879 Clinical Trial.

References

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    1. Ho CY, Day SM, Ashley EA, et al. Genotype and lifetime burden of disease in hypertrophic cardiomyopathy: insights from the Sarcomeric Human Cardiomyopathy Registry (SHaRe). Circulation 2018;138:1387–98. - PMC - PubMed
    1. Ho CY, Mealiffe ME, Bach RG, et al. Evaluation of mavacamten in symptomatic patients with nonobstructive hypertrophic cardiomyopathy. J Am Coll Cardiol 2020;75: 2649–60. - PubMed
    1. Rohde JA, Roopnarine O, Thomas DD, Muretta JM. Mavacamten stabilizes an auto-inhibited state of two-headed cardiac myosin. Proc Natl Acad Sci U S A 2018;115: E7486–94. - PMC - PubMed
    1. Anderson RL, Trivedi DV, Sarkar SS, et al. Deciphering the super relaxed state of human beta-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers. Proc Natl Acad Sci U S A 2018;115: E8143–52. - PMC - PubMed