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. 2021 Mar 1;41(3):602-609.
doi: 10.1097/IAE.0000000000002864.

CHOROIDAL GRANULOMAS VISUALIZED BY SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

Francesco Pichi  1   2 , Scott D Smith  1   2 , Piergiorgio Neri  1   2 , Elizabeth Woodstock  1 , Steven Hay  1 , Salvatore Parrulli  3 , Federico Corvi  3 , Chiara Mapelli  4 , Alessandro Invernizzi  3   5
Affiliations

CHOROIDAL GRANULOMAS VISUALIZED BY SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

Francesco Pichi et al. Retina. .

Abstract

Purpose: To assess the visualization of choroidal granulomas with swept-source optical coherence tomography angiography (OCTA).

Methods: Consecutive patients with granulomatous choroiditis due to tuberculosis, sarcoidosis, or Vogt-Koyanagi-Harada disease underwent baseline OCTA images using a 12 × 12-mm field of view, and the choroidal slabs were analyzed by two independent examiners who counted the oval areas of flow void. Simultaneously, indocyanine green angiography (ICGA) and enhanced-depth imaging OCT were performed to mark visible choroidal changes corresponding to granulomatous lesions. The lesion areas on OCTA and ICGA were assessed using the in-built caliper tool.

Results: Three hundred and one round-shaped areas of flow void on OCTA, 209 hypofluorescent round lesions on ICGA, and 42 hyporeflective choroidal lesions on enhanced-depth imaging OCT were identified in 23 eyes from 14 patients. Of the 209 ICGA granulomas, 197 (94.3%) had a corresponding round area of flow void on OCTA that was interpreted as a granuloma. One hundred and four additional round flow voids were identified on OCTA that did not correspond to any hypofluorescent lesion on ICGA. The mean area of the 197 granulomas detected with both imaging modalities was significantly larger on ICGA (mean 0.33 mm2) than that on OCTA (mean 0.28 mm2).

Conclusion: Optical coherence tomography angiography seems to be an optimal imaging method for the visualization of choroidal granulomas.

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