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. 2020 Jul;17(7):771-772.
doi: 10.1038/s41423-020-0473-0. Epub 2020 May 28.

More bricks in the wall against SARS-CoV-2 infection: involvement of γ9δ2 T cells

Ger Rijkers  1   2   3 , Trees Vervenne  4 , Pieter van der Pol  4
Affiliations

More bricks in the wall against SARS-CoV-2 infection: involvement of γ9δ2 T cells

Ger Rijkers et al. Cell Mol Immunol. 2020 Jul.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Reduced Vγ9Vδ2 T-cell numbers in SARS-CoV-2 infected patients with fatal outcome. Heparinized peripheral blood was incubated with a combination of CD45 V500, CD3 PerCP, CD4 PECy7, CD8 APC-H7, Vγ9 TCR PE, and Vδ2 TCR FITC labeled antibodies (see specifications in Supplementary Table 2) and measured by flow cytometry on a BD FACSLyric instrument (BD Biosciences, San Jose, CA, USA). Data analysis was performed with Infinicyt flow cytometry software (Cytognos, Capelle aan de IJssel, The Netherlands). Lymphocytes were gated on basis of CD45 and scatter characteristics. a, b Show the percentage of CD3+, CD4−, CD8 bright− T-lymphocytes expressing Vγ9 TCR and/or Vδ2 TCR of a representative COVID-19 patient and a healthy control donor, respectively. The boxed areas represents the Vγ9Vδ2 TCR T lymphocytes. c The numbers of Vγ9Vδ2 TCR T lymphocytes per ml are given for healthy controls and COVID-19 patients that died or survived. Patients who died of COVID-19 had a significant lower number of Vγ9Vδ2 TCR T lymphocytes (*p < 0.05 by two-sided Student T test). N.S. not significant
See this image and copyright information in PMC

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