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. 2020 Jul;17(7):773-775.
doi: 10.1038/s41423-020-0474-z. Epub 2020 May 28.

Serum IgA, IgM, and IgG responses in COVID-19

Huan Ma #  1   2 , Weihong Zeng #  1   2 , Hongliang He #  3 , Dan Zhao  2 , Dehua Jiang  4 , Peigen Zhou  5 , Linzhao Cheng  6   7 , Yajuan Li  8 , Xiaoling Ma  9 , Tengchuan Jin  10
Affiliations

Serum IgA, IgM, and IgG responses in COVID-19

Huan Ma et al. Cell Mol Immunol. 2020 Jul.
No abstract available

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Conflict of interest statement

Dehua Jiang is an employee of Kangrun Biotech LTD (Guangzhou, China). Tengchuan Jin, Huan Ma, Weihong Zeng in USTC and Dehua Jiang have applied a joining patent related to the antibody detecting kits. Other authors declare that they have no conflicts of interest.

Figures

Fig. 1
Fig. 1
Analysis of SARS-CoV-2 RBD-specific IgA, IgM, and IgG antibodies in 87 COVID-19 patients. Testing results of RBD-specific IgA (a), IgM (b), and IgG (c) kits using 330 healthy sera, 138 sera from other-type of patients who may interfere with the test, 15 sera of once-suspected pneumonia patients, and 216 sera of 87 qPCR-confirmed COVID-19 patients. RLU relative light units. Black bar indicates median values. The dotted line indicates the cut-off value for detecting of each isotypes of antibodies. d Sensitivity of RBD-specific IgA, IgM, and IgG detection in serum samples obtained at different periods after illness onset. The kinetics of anti-RBD IgA, IgM, and IgG levels in sera of COVID-19 patients at different time windows was analyzed (e). The median values of RLU were plotted for each isotype of three antibodies. Bars indicate median with interquartile ranges. f–h Serum antibody levels in healthy and three distinct severity groups of COVID-19 patients were analyzed. Healthy: 330 sera; Mild: 7 sera; Moderate: 44 sera; and Severe: 21 sera. The critically ill patients were included into the severe group. Only the data of serum antibody levels at 16–25 days after illness onset of COVID-19 patients were used
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References

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