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Review
. 2020 May 14:16:36.
doi: 10.1186/s13223-020-00434-0. eCollection 2020.

Quercetin with the potential effect on allergic diseases

Morteza Jafarinia  1 , Mahnaz Sadat Hosseini  1 , Neda Kasiri  1 , Niloofar Fazel  1 , Farshid Fathi  1 , Mazdak Ganjalikhani Hakemi  1 , Nahid Eskandari  1   2
Affiliations
Review

Quercetin with the potential effect on allergic diseases

Morteza Jafarinia et al. Allergy Asthma Clin Immunol. .

Abstract

Quercetin is a naturally occurring polyphenol flavonoid which is rich in antioxidants. It has anti-allergic functions that are known for inhibiting histamine production and pro-inflammatory mediators. Quercetin can regulate the Th1/Th2 stability, and decrease the antigen-specific IgE antibody releasing by B cells. Quercetin has a main role in anti-inflammatory and immunomodulatory function which makes it proper for the management of different diseases. Allergic diseases are a big concern and have high health care costs. In addition, the use of current therapies such as ß2-agonists and corticosteroids has been limited for long term use due to their numerous side effects. Since the effect of quercetin on allergic diseases has been widely studied, in the current article, we review the effect of quercetin on allergic diseases, such as allergic asthma, allergic rhinitis (AR), and atopic dermatitis (AD).

Keywords: Allergy; Asthma; Quercetin.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Structure of quercetin
Fig. 2
Fig. 2
Different effects of quercetin on immune cells involved in asthma
See this image and copyright information in PMC

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