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Review
. 2020 Jul;24(14):7686-7696.
doi: 10.1111/jcmm.15348. Epub 2020 May 29.

Expression, function and clinical application of stanniocalcin-1 in cancer

Fangyu Zhao  1 , Gang Yang  1 , Mengyu Feng  1 , Zhe Cao  1 , Yueze Liu  1 , Jiangdong Qiu  1 , Lei You  1 , Lianfang Zheng  2 , Taiping Zhang  1   3 , Yupei Zhao  1
Affiliations
Review

Expression, function and clinical application of stanniocalcin-1 in cancer

Fangyu Zhao et al. J Cell Mol Med. 2020 Jul.

Abstract

The glycoprotein stanniocalcin-1 functions as a regulatory endocrine hormone that maintains the balance of calcium and phosphorus in bony fish and as a paracrine/autocrine factor involved in many physiological/pathological processes in humans, including carcinogenesis. In this review, we provide an overview of (a) the possible mechanisms through which STC1 affects the malignant properties of cancer, (b) transcriptional and post-transcriptional regulation pathways of STC1 and (c) the potential clinical relevance of STC1 as a cancer biomarker and even a therapeutic target in the future. Exploring the role of STC1 in cancer development may provide a better understanding of the tumorigenesis process in humans and may facilitate finding an effective therapeutic method against cancer.

Keywords: biomarker; cancer development; clinical application; stanniocalcin-1.

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Conflict of interest statement

None declared.

Figures

FIGURE 1
FIGURE 1
Regulation networks of STC1. STC1 is regulated by many proteins, and it can affect several signalling pathways to modulate tumour phenotypes
FIGURE 2
FIGURE 2
STC1 and hypoxia. HIF, hypoxia inducible factor; HRE, hypoxia response element; UCP, uncoupling protein; ROS, reactive oxygen species
See this image and copyright information in PMC

References

    1. Chang AC, Dunham MA, Jeffrey KJ, Reddel RR. Molecular cloning and characterization of mouse stanniocalcin cDNA. Mol Cell Endocrinol. 1996;124:185‐187. - PubMed
    1. Yeung BH, Law AY, Wong CK. Evolution and roles of stanniocalcin. Mol Cell Endocrinol. 2012;349:272‐280. - PubMed
    1. Sundell K, Bjornsson BT, Itoh H, Kawauchi H. Chum salmon (Oncorhynchus keta) stanniocalcin inhibits in vitro intestinal calcium uptake in Atlantic cod (Gadus morhua). J Comp Physiol B. 1992;162:489‐495. - PubMed
    1. Olsen HS, Cepeda MA, Zhang QQ, Rosen CA, Vozzolo BL. Human stanniocalcin: a possible hormonal regulator of mineral metabolism. Proc Natl Acad Sci USA. 1996;93:1792‐1796. - PMC - PubMed
    1. Chang AC, Jellinek DA, Reddel RR. Mammalian stanniocalcins and cancer. Endocr Relat Cancer. 2003;10:359‐373. - PubMed

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