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. 2020 May 29;15(5):e0232634.
doi: 10.1371/journal.pone.0232634. eCollection 2020.

Are serum levels of inhibin A in second trimester predictors of adverse pregnancy outcome?

Chao-Yan Yue  1 , Chun-Yi Zhang  1 , Ying-Hua Ni  1 , Chun-Mei Ying  1
Affiliations

Are serum levels of inhibin A in second trimester predictors of adverse pregnancy outcome?

Chao-Yan Yue et al. PLoS One. .

Abstract

Objective: During pregnancy, inhibin A is mainly derived from the placenta and regulates the implantation and differentiation of embryos. Our aim was to assess whether second trimester serum inhibin A was associated with an increased risk of adverse pregnancy outcomes.

Methods: We investigated the serum levels of Inhibin A during the second trimester in pregnancy, and analyzed associations between the Inhibin A and the risk of adverse pregnancy outcome. 12,124 pregnant women were enrolled in this study between January 2017 and July 2019 at the Obstetrics & Gynecology Hospital of Fudan University. Multivariate logistic regression analysis was conducted to estimate the relative risk between Inhibin A and adverse pregnancy outcome.

Results: Compared with the group without adverse pregnancy outcome, during the second trimester of pregnancy, age and Inhibin A were risk factors for pre-eclampsia, gestational diabetes mellitus and preterm delivery; Inhibin A was risk factors for low birth weight. Gravidity and Inhibin A were risk factors for macrosomia; while parity was a protective factor against pre-eclampsia, gestational hypertension and low birth weight.

Conclusion: Elevated Inhibin A levels in pregnancy are significantly associated with pre-eclampsia, GDM, macrosomia, low birth weight and preterm delivery.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Incidence of adverse pregnancy outcomes at different inhibin A MOM values.
The blue dots were incidence in the population divided into 19 groups according to inhibin A MOM.
See this image and copyright information in PMC

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References

    1. de Kretser DM, Hedger MP, Loveland KL, Phillips DJ. Inhibins, activins and follistatin in reproduction. Hum Reprod Update, 2002; 8: 529–541. - PubMed
    1. Florio P, Cobellis L, Luisi S et al. Changes in inhibins and activin secretion in healthy and pathological pregnancies. Mol Cell Endocrinol, 2001; 180: 123–130. - PubMed
    1. Muttukrishna S, Child TJ, Groome NP, Ledger WL. Source of circulating levels of inhibin A, pro alpha C-containing inhibins and activin A in early pregnancy. Hum Reprod, 1997; 12: 1089–1093. - PubMed
    1. Yu J, Shixia CZ, Wu Y, Duan T. Inhibin A, activin A, placental growth factor and uterine artery Doppler pulsatility index in the prediction of pre-eclampsia. Ultrasound Obst Gyn, 2011;37(5):528–33. - PubMed
    1. Brown LF, Shearing CH, Tydeman G. Stability of inhibin A and unconjugated oestriol in the second trimester of pregnancy. Ann Clin Biochem, 2011;48(Pt 1):72–4. - PubMed

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