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Meta-Analysis
. 2020 May 29;15(5):e0233629.
doi: 10.1371/journal.pone.0233629. eCollection 2020.

Prognostic value of LAT-1 status in solid cancer: A systematic review and meta-analysis

Jing-Jing Lu  1 , Ping Li  1 , Yong Yang  2 , Le Wang  1 , Yan Zhang  1 , Jia-Yao Zhu  1 , Xiao-Ren Zhu  1 , Min-Bin Chen  1
Affiliations
Meta-Analysis

Prognostic value of LAT-1 status in solid cancer: A systematic review and meta-analysis

Jing-Jing Lu et al. PLoS One. .

Abstract

Background: The expression of the L-type amino acid transporter 1 (LAT1) plays a significant role in tumor progression. However, it remains unclear whether high LAT1 expression correlates with poor prognosis of solid tumor patients. Here, we conducted a meta-analysis to assess the potential of LAT1 in predicting the prognosis of tumor patients.

Methods and findings: A total of 4,579 cases were analyzed from 35 qualified studies. In patients with solid tumors, elevated expression of LAT1 is associated with poor prognosis (overall survival [OS]: pooled hazard ratio (HR) = 1.848, 95% confidence interval (CI) = 1.620-2.108, P < 0.001; disease free survival [DFS]: pooled HR = 1.923, 95% CI = 1.585-2.333, P < 0.001; progression free survival [PFS]: pooled HR = 1.345, 95% CI = 1.133-1.597, P = 0.001). Furthermore, in subgroup analysis, we found an association between high LAT1 expression and poor OS in non-small cell lung cancer (HR = 1.554, 95% CI = 1.345-1.794, P < 0.001), pancreatic cancer (HR = 2.052, 95% CI = 1.613-2.724, P < 0.001) and biliary tract cancer (HR = 2.253, 95% CI = 1.562-3.227, P < 0.001).

Conclusion: The results of this meta-analysis indicate the reliability and potential of using LAT1 expression as a predictive biomarker in solid cancers prior to treatment. However, further studies with larger sample sizes would be beneficial for fully evaluating the predictive value of LAT1 expression for clinical applications.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The flow chart of the selection process in our meta-analysis.
Fig 2
Fig 2. The correlation between LAT1 high expression and overall survival (OS) of solid cancers.
Fig 3
Fig 3. The correlation between LAT1 high expression and disease free survival (DFS).
Fig 4
Fig 4. The correlation between LAT1 high expression and progression free survival (PFS).
Fig 5
Fig 5. Begg’s funnel plots for the studies involved in the meta-analysis.
A. overall survival B: progression free survival. C. disease free survival. Abbreviations: loghr, logarithm of HRs; s.e., standard error.
Fig 6
Fig 6. Sensitivity analysis of the meta-analysis.
A. overall survival B: progression free survival. C disease free survival.
See this image and copyright information in PMC

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