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Comment
. 2020 Jun 8;37(6):759-760.
doi: 10.1016/j.ccell.2020.05.009. Epub 2020 May 28.

Seeking Cellular Fitness and Immune Evasion: Autophagy in Pancreatic Carcinoma

Guido Kroemer  1 , Laurence Zitvogel  2
Affiliations
Free article
Comment

Seeking Cellular Fitness and Immune Evasion: Autophagy in Pancreatic Carcinoma

Guido Kroemer et al. Cancer Cell. .
Free article

Abstract

In a recent Nature paper, Yamamoto et al. demonstrate that, in the particular context of pancreatic carcinoma, autophagy causes the continuous destruction of major histocompatibility complex class I (MHC-I) proteins. Suppression of autophagy favors MHC-I re-appearance on the surface of malignant cells, facilitating their clearance by cytotoxic T lymphocytes.

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Conflict of interest statement

Declaration of Interests L.Z. and G.K. are the scientific co-founders of everImmune. G.K. is a scientific co-founder of Samsara Therapeutics and Therafast Bio.

Comment on

  • Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I.
    Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC. Yamamoto K, et al. Nature. 2020 May;581(7806):100-105. doi: 10.1038/s41586-020-2229-5. Epub 2020 Apr 22. Nature. 2020. PMID: 32376951 Free PMC article.

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