Biasing Neurotensin Receptor Signaling to Arrest Psychostimulant Abuse

Abstract

Biasing G protein-coupled receptor signaling with ligands that promote select pathways is emerging as a powerful approach for therapeutic drug discovery. In this issue of Cell, Slosky et al. report a β-arrestin-biased neurotensin receptor ligand that may curtail drug abuse without the side effects induced by G protein signaling.