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. 2020 May 28;181(5):1188-1188.e1.
doi: 10.1016/j.cell.2020.04.039.

SnapShot: Ferroptosis

Kamyar Hadian  1 , Brent R Stockwell  2
Affiliations

SnapShot: Ferroptosis

Kamyar Hadian et al. Cell. .

Abstract

Ferroptosis is a regulated form of cell death that occurs when phospholipids with polyunsaturated fatty acyl tails are oxidized in an iron-dependent manner. Research in recent years has uncovered complex cellular networks that induce and suppress lethal lipid peroxidation. This SnapShot provides an overview of ferroptosis-related pathways, including relevant biomolecules and small-molecule modulators regulating them.

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Conflict of interest statement

Declaration of Interests

B.R.S. is an inventor on patents and patent applications involving ferroptosis, and co-founded, serves as a consultant to Inzen Therapeutics and Nevrox Ltd. K.H. declares no competing interests.

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